PHCCC [Ligand Id: 1416] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL164770
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
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  • mGlu4 receptor in Human [GtoPdb: 292] [UniProtKB: Q14833]
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  • mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
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  • mGlu6 receptor in Rat [GtoPdb: 294] [UniProtKB: P35349]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
ChEMBL Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells. B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem Lett (1996) 6: 763-766
mGlu4 receptor in Human [GtoPdb: 292] [UniProtKB: Q14833]
GtoPdb - - 4.5 pEC50 - - - Neuropharmacology (2003) 45: 895-906 [PMID:14573382]
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
mGlu6 receptor in Rat [GtoPdb: 294] [UniProtKB: P35349]
GtoPdb - - 4.8 pEC50 15000 nM EC50 Eur J Pharmacol (2008) 589: 49-52 [PMID:18593581]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]