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ChEMBL ligand: CHEMBL164770 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] | ||||||||
ChEMBL | Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells. | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg. Med. Chem. Lett. (1996) 6: 763-766 |
mGlu4 receptor in Human [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
GtoPdb | - | - | 4.5 | pEC50 | - | - | - | Neuropharmacology (2003) 45: 895-906 [PMID:14573382] |
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
mGlu6 receptor in Rat [GtoPdb: 294] [UniProtKB: P35349] | ||||||||
GtoPdb | - | - | 4.8 | pEC50 | 15000 | nM | EC50 | Eur J Pharmacol (2008) 589: 49-52 [PMID:18593581] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]