PHCCC [Ligand Id: 1416] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL164770
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
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  • mGlu4 receptor in Human [GtoPdb: 292] [UniProtKB: Q14833]
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  • mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
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  • mGlu6 receptor in Rat [GtoPdb: 294] [UniProtKB: P35349]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
ChEMBL Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells. B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 763-766
mGlu4 receptor in Human [GtoPdb: 292] [UniProtKB: Q14833]
GtoPdb - - 4.5 pEC50 - - - Neuropharmacology (2003) 45: 895-906 [PMID:14573382]
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
mGlu6 receptor in Rat [GtoPdb: 294] [UniProtKB: P35349]
GtoPdb - - 4.8 pEC50 15000 nM EC50 Eur J Pharmacol (2008) 589: 49-52 [PMID:18593581]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]