ChEMBL ligand: CHEMBL190270
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL	Displacement of [3H]-MPEP from human mGluR5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 7381-7384 [PMID:21067920]
ChEMBL	Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay	F	6.75	pEC50	177.83	nM	EC50	J Med Chem (2013) 56: 7243-7259 [PMID:23947773]
ChEMBL	Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay	F	6.75	pEC50	176	nM	EC50	J Med Chem (2013) 56: 7243-7259 [PMID:23947773]
ChEMBL	Positive allosteric modulation of human mGluR5 stably expressed in CHO cells assessed as Ca2+ flux by FLIPR assay	F	7.57	pEC50	27	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
GtoPdb	-	-	8	pEC50	-	-	-	J Pharmacol Exp Ther (2005) 313: 199-206 [PMID:15608073]; J Med Chem (2004) 47: 5825-8 [PMID:15537338]
ChEMBL	Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cells	B	8	pEC50	10	nM	EC50	J Med Chem (2004) 47: 5825-5828 [PMID:15537338]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL	Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells	B	5.42	pKi	3760	nM	Ki	J Med Chem (2006) 49: 3332-3344 [PMID:16722652]
ChEMBL	Positive allosteric modulation of rat mGluR5 stably expressed in CHO cells assessed as Ca2+ flux by FLIPR assay	F	7.01	pEC50	98	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
ChEMBL	Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes	F	7.11	pEC50	77	nM	EC50	J Med Chem (2006) 49: 3332-3344 [PMID:16722652]
ChEMBL	Effective concentration against metabotropic glutamate receptor 5 of rat	B	7.7	pEC50	20	nM	EC50	J Med Chem (2004) 47: 5825-5828 [PMID:15537338]
GtoPdb	-	-	7.7	pEC50	-	-	-	J Med Chem (2004) 47: 5825-8 [PMID:15537338]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]