leptomycin B [Ligand Id: 14274] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL486133
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
exportin 1/Exportin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5661] [GtoPdb: 3014] [UniProtKB: O14980]
ChEMBL Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization competition binding assay B 6.82 pIC50 151 nM IC50 J Med Chem (2020) 63: 7545-7558 [PMID:32585100]
ChEMBL Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assay B 9 pIC50 1 nM IC50 J Med Chem (2017) 60: 839-885 [PMID:27996267]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]