MTEB [Ligand Id: 1428] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL201943 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Displacement of [3H]MPEP from cloned human mGluR5 transfected in HEK293-T cells | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
| GtoPdb | - | - | 8.7 | pIC50 | - | - | - | Bioorg Med Chem (2004) 12: 17-21 [PMID:14697765] |
| ChEMBL | Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5a | F | 9.03 | pIC50 | 0.94 | nM | IC50 | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Displacement of [3H]MPEP from mGluR5 in rat brain membranes | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
