MTEB [Ligand Id: 1428] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL201943 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Displacement of [3H]MPEP from cloned human mGluR5 transfected in HEK293-T cells | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
| GtoPdb | - | - | 8.7 | pIC50 | - | - | - | Bioorg Med Chem (2004) 12: 17-21 [PMID:14697765] |
| ChEMBL | Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5a | F | 9.03 | pIC50 | 0.94 | nM | IC50 | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Displacement of [3H]MPEP from mGluR5 in rat brain membranes | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2006) 49: 1080-1100 [PMID:16451073] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
