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ChEMBL ligand: CHEMBL201943 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
ChEMBL | Displacement of [3H]MPEP from cloned human mGluR5 transfected in HEK293-T cells | B | 9.43 | pKi | 0.37 | nM | Ki | J. Med. Chem. (2006) 49: 1080-1100 [PMID:16451073] |
GtoPdb | - | - | 8.7 | pIC50 | - | - | - | Bioorg Med Chem (2004) 12: 17-21 [PMID:14697765] |
ChEMBL | Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5a | F | 9.03 | pIC50 | 0.94 | nM | IC50 | J. Med. Chem. (2006) 49: 1080-1100 [PMID:16451073] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
ChEMBL | Displacement of [3H]MPEP from mGluR5 in rat brain membranes | B | 9.6 | pKi | 0.25 | nM | Ki | J. Med. Chem. (2006) 49: 1080-1100 [PMID:16451073] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]