MTEB [Ligand Id: 1428] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL201943
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Displacement of [3H]MPEP from cloned human mGluR5 transfected in HEK293-T cells B 9.43 pKi 0.37 nM Ki J Med Chem (2006) 49: 1080-1100 [PMID:16451073]
GtoPdb - - 8.7 pIC50 - - - Bioorg Med Chem (2004) 12: 17-21 [PMID:14697765]
ChEMBL Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5a F 9.03 pIC50 0.94 nM IC50 J Med Chem (2006) 49: 1080-1100 [PMID:16451073]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Displacement of [3H]MPEP from mGluR5 in rat brain membranes B 9.6 pKi 0.25 nM Ki J Med Chem (2006) 49: 1080-1100 [PMID:16451073]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]