ChEMBL ligand: CHEMBL239800 (Fenobam, MCN-3377-98)
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] There should be some charts here, you may need to enable JavaScript!
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
ChEMBL	Antagonist activity at human mGLUR1	F	8.17	pKi	6.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4371-4375 [PMID:20615697]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL	Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometry	B	6.79	pKi	162.2	nM	Ki	Bioorg Med Chem (2015) 23: 3040-3058 [PMID:26014480]
ChEMBL	Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis	B	6.79	pKi	162.2	nM	Ki	J Med Chem (2019) 62: 1246-1273 [PMID:30624919]
ChEMBL	Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting method	B	7.48	pKi	33	nM	Ki	Bioorg Med Chem (2018) 26: 4797-4803 [PMID:30143366]
ChEMBL	Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting method	B	7.5	pKi	31.62	nM	Ki	Bioorg Med Chem (2018) 26: 4797-4803 [PMID:30143366]
ChEMBL	Binding affinity to human mGluR5	B	8.17	pKi	6.76	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3737-3741 [PMID:20483612]
ChEMBL	Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR	F	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1142-1145 [PMID:16380255]
GtoPdb	-	-	7.2	pIC50	-	-	-	J Pharmacol Exp Ther (2005) 315: 711-21 [PMID:16040814]
ChEMBL	Displacement of [3H]MPEP from mGlu5 receptor	B	7.21	pIC50	61	nM	IC50	Bioorg Med Chem Lett (2007) 17: 1307-1311 [PMID:17196387]
ChEMBL	Displacement of [3H]-MPEP from human mGlu5 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting analysis	B	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1249-1252 [PMID:26774652]
ChEMBL	Antagonist activity at human mGluR5 expressed in CHO-K1 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization	F	7.37	pIC50	43	nM	IC50	ACS Med Chem Lett (2011) 2: 882-884 [PMID:22523618]
ChEMBL	Antagonist activity at mGluR5 by FLIPR	F	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2007) 17: 1307-1311 [PMID:17196387]
ChEMBL	Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced calcium mobilization treated 10 mins prior to agonist application by fluorescence analysis	F	7.44	pIC50	36.3	nM	IC50	Bioorg Med Chem (2015) 23: 3040-3058 [PMID:26014480]
ChEMBL	Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobilization incubated for 18 hrs and measured every 1.5 secs intervals for 60 secs by Fluo-4/AM dye-based fluorescence analysis	F	7.44	pIC50	36.3	nM	IC50	J Med Chem (2019) 62: 1246-1273 [PMID:30624919]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL	Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometry	B	6.5	pKi	312.7	nM	Ki	Bioorg Med Chem (2015) 23: 3040-3058 [PMID:26014480]
ChEMBL	Displacement of [3H]MPEP from mGluR5d in rat brain membrane	B	6.34	pIC50	460	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1142-1145 [PMID:16380255]
ChEMBL	Displacement of [3H]-MPEP from rat mGlu5 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting analysis	B	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1249-1252 [PMID:26774652]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]