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ChEMBL ligand: CHEMBL525634 (H-Motilin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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motilin receptor/Motilin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193] | ||||||||
GtoPdb | - | - | 8.7 | pKi | - | - | - |
J Pharmacol Exp Ther (2005) 313: 1101-8 [PMID:15677347]; J Biol Chem (2001) 276: 35518-22 [PMID:11461914]; J Biol Chem (2002) 277: 9834-9 [PMID:11781320]; J Biol Chem (2006) 281: 12390-6 [PMID:16531413] |
ChEMBL | Agonist activity at human GPR38 expressed in COS-7 cells | F | 9.01 | pEC50 | 0.97 | nM | EC50 | Bioorg Med Chem Lett (2022) 59: 128554-128554 [PMID:35051575] |
ChEMBL | Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay | F | 10.4 | pEC50 | 0.04 | nM | EC50 | J Med Chem (2009) 52: 1180-1189 [PMID:19191554] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]