BIBO3304 [Ligand Id: 1528] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1774204
  • Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
  • Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555]
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  • Y4 receptor/Neuropeptide Y receptor type 4 in Human [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells B 9.6 pKi 0.25 nM Ki Bioorg. Med. Chem. (2011) 19: 2859-2878 [PMID:21493077]
GtoPdb - - 9.5 pIC50 0.38 nM IC50 Br J Pharmacol (1998) 125: 549-555 [PMID:9806339]
Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555]
GtoPdb - - 9.7 pIC50 - - - Br J Pharmacol (2000) 129: 37-46 [PMID:10694200]
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391]
ChEMBL Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysis B 5.3 pKi >5000 nM Ki Bioorg. Med. Chem. (2013) 21: 6303-6322 [PMID:24074877]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]