levocabastine [Ligand Id: 1586] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1615438 (Levocabastine, Livostin direct, R-50547)
  • NTS2 receptor in Human [GtoPdb: 310] [UniProtKB: O95665]
  • NTS2 receptor in Mouse [GtoPdb: 310] [UniProtKB: P70310]
  • NTS2 receptor/Neurotensin receptor 2 in Rat [ChEMBL: CHEMBL5106] [GtoPdb: 310] [UniProtKB: Q63384]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NTS2 receptor in Human [GtoPdb: 310] [UniProtKB: O95665]
GtoPdb - - 6.8 pKi - - - Mol Pharmacol (2001) 60: 1392-8 [PMID:11723247];
J Neurosci (1996) 16: 5613-20 [PMID:8795617]
NTS2 receptor in Mouse [GtoPdb: 310] [UniProtKB: P70310]
GtoPdb - - 8.7 pIC50 - - - Biochem Biophys Res Commun (1998) 243: 585-90 [PMID:9480852]
NTS2 receptor/Neurotensin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5106] [GtoPdb: 310] [UniProtKB: Q63384]
ChEMBL Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting B 7.48 pKi 33 nM Ki J. Med. Chem. (2014) 57: 5318-5332 [PMID:24856674]
GtoPdb - - 8 pIC50 - - - FEBS Lett (1996) 386: 91-4 [PMID:8647296]
ChEMBL Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay F 7.55 pEC50 28 nM EC50 J. Med. Chem. (2014) 57: 5318-5332 [PMID:24856674]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]