levocabastine [Ligand Id: 1586] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1615438 (Levocabastine, Livostin direct, R-50547)
  • NTS2 receptor in Human [GtoPdb: 310] [UniProtKB: O95665]
  • NTS2 receptor in Mouse [GtoPdb: 310] [UniProtKB: P70310]
  • NTS2 receptor/Neurotensin receptor 2 in Rat [ChEMBL: CHEMBL5106] [GtoPdb: 310] [UniProtKB: Q63384]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NTS2 receptor in Human [GtoPdb: 310] [UniProtKB: O95665]
GtoPdb - - 6.8 pKi - - - Mol Pharmacol (2001) 60: 1392-8 [PMID:11723247];
J Neurosci (1996) 16: 5613-20 [PMID:8795617]
NTS2 receptor in Mouse [GtoPdb: 310] [UniProtKB: P70310]
GtoPdb - - 8.7 pIC50 - - - Biochem Biophys Res Commun (1998) 243: 585-90 [PMID:9480852]
NTS2 receptor/Neurotensin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5106] [GtoPdb: 310] [UniProtKB: Q63384]
ChEMBL Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting B 7.48 pKi 33 nM Ki J Med Chem (2014) 57: 5318-5332 [PMID:24856674]
GtoPdb - - 8 pIC50 - - - FEBS Lett (1996) 386: 91-4 [PMID:8647296]
ChEMBL Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay F 7.55 pEC50 28 nM EC50 J Med Chem (2014) 57: 5318-5332 [PMID:24856674]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]