levocabastine [Ligand Id: 1586] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1615438 (Levocabastine, Livostin direct, R-50547) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NTS2 receptor in Human [GtoPdb: 310] [UniProtKB: O95665] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | - | - | - |
Mol Pharmacol (2001) 60: 1392-8 [PMID:11723247]; J Neurosci (1996) 16: 5613-20 [PMID:8795617] |
| NTS2 receptor in Mouse [GtoPdb: 310] [UniProtKB: P70310] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | - | - | - | Biochem Biophys Res Commun (1998) 243: 585-90 [PMID:9480852] |
| NTS2 receptor/Neurotensin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5106] [GtoPdb: 310] [UniProtKB: Q63384] | ||||||||
| ChEMBL | Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2014) 57: 5318-5332 [PMID:24856674] |
| GtoPdb | - | - | 8 | pIC50 | - | - | - | FEBS Lett (1996) 386: 91-4 [PMID:8647296] |
| ChEMBL | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay | F | 7.55 | pEC50 | 28 | nM | EC50 | J Med Chem (2014) 57: 5318-5332 [PMID:24856674] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
