ethylketocyclazocine [Ligand Id: 1602] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL71301
  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
  • κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
  • μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Mouse [ChEMBL: CHEMBL3465] [GtoPdb: 2552] [UniProtKB: O55242]
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  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 10 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL Binding affinity for mouse opioid receptor kappa B 8.22 pKi 6 nM Ki J. Med. Chem. (1989) 32: 2221-2226 [PMID:2549247]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 9.5 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL Binding affinity for mouse opioid receptor mu B 8.89 pKi 1.3 nM Ki J. Med. Chem. (1989) 32: 2221-2226 [PMID:2549247]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3465] [GtoPdb: 2552] [UniProtKB: O55242]
ChEMBL Binding affinity for mouse sigma opioid receptor B 8.64 pKi 2.3 nM Ki J. Med. Chem. (1989) 32: 2221-2226 [PMID:2549247]
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 8.5 pKi 3.16 nM Ki NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]