ChEMBL ligand: CHEMBL560 (Pentazocine)
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
Sigma-1 receptor in Guinea pig [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] σ2/Sigma intracellular receptor 2 in Rat [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	-	-	8.6	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]; J Pharmacol Exp Ther (1997) 282: 676-84 [PMID:9262330]
ChEMBL	Binding affinity to kappa opioid receptor (unknown origin)	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	-	-	8.4	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Binding affinity to mu opioid receptor (unknown origin)	B	8.41	pKi	3.9	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes measured after 120 mins by scintillation counting method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 237: 114359-114359 [PMID:35468513]
ChEMBL	Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membrane incubated for 120 mins by liquid scintillation counting method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 210: 112950-112950 [PMID:33148494]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by solid scintillation counting method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 219: 113443-113443 [PMID:33901806]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by competitive radioligand receptor binding assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 230: 114113-114113 [PMID:35065412]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured by competitive radioligand receptor binding assay	B	8.27	pKi	5.4	nM	Ki	Eur J Med Chem (2022) 230: 114079-114079 [PMID:35033825]
ChEMBL	Displacement of [3H]-pentazocine from guinea pig brain sigma 1 receptor incubated for 120 mins by liquid scintillation counting method	B	8.27	pKi	5.4	nM	Ki	RSC Med Chem (2021) 12: 237-244 [PMID:34046612]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting method	B	8.33	pKi	4.7	nM	Ki	ACS Med Chem Lett (2020) 11: 889-894 [PMID:32435401]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting method	B	8.33	pKi	4.7	nM	Ki	J Med Chem (2021) 64: 890-904 [PMID:33372782]
ChEMBL	Displacement of [3H]-(+)-pentazocine from Dunkin-Hartley guinea pig brain cortex Sigma 1 receptor incubated for 150 mins by liquid scintillation counting analysis	B	8.37	pKi	4.3	nM	Ki	Eur J Med Chem (2022) 230: 114091-114091 [PMID:35016113]
ChEMBL	Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 120 mins by scintillation counting method	B	8.41	pKi	3.93	nM	Ki	Eur J Med Chem (2022) 228: 114038-114038 [PMID:34902734]
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	Binding affinity to sigma-2 receptor (unknown origin)	B	5.73	pKi	1880	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
ChEMBL	Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor (unknown origin) incubated for 1 hr in presence of (+)SKF10047 by liquid scintillation counting method	B	5.83	pKi	1465	nM	Ki	ACS Med Chem Lett (2020) 11: 889-894 [PMID:32435401]
ChEMBL	Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constant by radioligand binding assay	B	5.83	pKi	1465	nM	Ki	Bioorg Med Chem Lett (2022) 72: 128860-128860 [PMID:35724925]
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL	Displacement of [3H]-DTG from Sprague-Dawley rat liver Sigma 2 receptor incubated for 120 mins in presence of [3H]-(+)-pentazocine by liquid scintillation counting analysis	B	5.83	pKi	1465	nM	Ki	Eur J Med Chem (2022) 230: 114091-114091 [PMID:35016113]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity to sigma-1 receptor (unknown origin)	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
ChEMBL	Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assay	B	8.33	pKi	4.7	nM	Ki	Bioorg Med Chem Lett (2022) 72: 128860-128860 [PMID:35724925]
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	-	-	7.3	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]