(-)-pentazocine [Ligand Id: 1606] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL560 (Pentazocine)
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  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by liquid scintillation counting method B 7.82 pKi 15 nM Ki Eur J Med Chem (2018) 156: 534-553 [PMID:30025348]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting method B 8.27 pKi 5.4 nM Ki J Med Chem (2018) 61: 9666-9690 [PMID:30350997]
ChEMBL Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysis B 8.27 pKi 5.4 nM Ki MedChemComm (2016) 7: 2368-2380
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 7.3 pKi - - - NIDA Res. Monogr. (1998) 178: 440-66 [PMID:9686407]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 8.6 pKi - - - NIDA Res. Monogr. (1998) 178: 440-66 [PMID:9686407];
J. Pharmacol. Exp. Ther. (1997) 282: 676-84 [PMID:9262330]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.4 pKi - - - NIDA Res. Monogr. (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]