dynorphin B [Ligand Id: 1622] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL500830
  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
There should be some charts here, you may need to enable JavaScript!
  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
  • κ receptor in Mouse [GtoPdb: 318] [UniProtKB: P33534]
  • κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
There should be some charts here, you may need to enable JavaScript!
  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 7.8 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 9.9 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407];
Binding and activity of opioid ligands at the cloned human delta, mu and kappa receptors.. The Delta Receptor (2003);
Proc Natl Acad Sci USA (1995) 92: 7006-10 [PMID:7624359]
κ receptor in Mouse [GtoPdb: 318] [UniProtKB: P33534]
GtoPdb - - 10 pIC50 - - - Proc Natl Acad Sci USA (1993) 90: 6736-40 [PMID:8393575]
κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
GtoPdb - - 9.5 pKi - - - Proc Natl Acad Sci USA (1993) 90: 9954-8 [PMID:8234341]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.5 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]