dynorphin B [Ligand Id: 1622] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL500830
  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
  • κ receptor in Mouse [GtoPdb: 318] [UniProtKB: P33534]
  • κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 7.8 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 9.9 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407];
Binding and activity of opioid ligands at the cloned human delta, mu and kappa receptors.. The Delta Receptor (2003);
Proc Natl Acad Sci USA (1995) 92: 7006-10 [PMID:7624359]
κ receptor in Mouse [GtoPdb: 318] [UniProtKB: P33534]
GtoPdb - - 10 pIC50 - - - Proc Natl Acad Sci USA (1993) 90: 6736-40 [PMID:8393575]
κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
GtoPdb - - 9.5 pKi - - - Proc Natl Acad Sci USA (1993) 90: 9954-8 [PMID:8234341]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.5 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]