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ChEMBL ligand: CHEMBL8600 (2-(2,5-Dimethoxy-4-Methyl-Phenyl)-1-Methyl-Ethylamine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396] | ||||||||
ChEMBL | Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension | B | 4.62 | pIC50 | 24000 | nM | IC50 | J. Med. Chem. (2005) 48: 2407-2419 [PMID:15801832] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampal tissue | B | 5.29 | pKi | 5125 | nM | Ki | J. Med. Chem. (1988) 31: 867-870 [PMID:2965244] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
ChEMBL | Binding affinity against 5-HT1B serotonin receptor in rat striatum | B | 5.68 | pKi | 2070 | nM | Ki | J. Med. Chem. (1988) 31: 867-870 [PMID:2965244] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
GtoPdb | - | - | 6.8 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 286: 85-90 [PMID:9655845] |
ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy | B | 7 | pKi | 100 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 4661-4669 [PMID:18296055] |
ChEMBL | Compound was evaluated for its ability to displace [125I](R)-DOI from 5-hydroxytryptamine 2A receptor in cloned rat prefrontal cortex homogenate | B | 7.72 | pKi | 19 | nM | Ki | Bioorg. Med. Chem. Lett. (2002) 12: 1997-1999 [PMID:12113827] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL323] [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
ChEMBL | Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus | B | 7.12 | pKd | 75.86 | nM | Kd | J. Med. Chem. (1981) 24: 1414-1421 [PMID:7310818] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand | B | 6.71 | pKi | 193 | nM | Ki | J. Med. Chem. (1992) 35: 734-740 [PMID:1542100] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]