ICI 204448 [Ligand Id: 1650] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23472 (ICI-204448) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of bound [3H]diprenorphine from membranes expressing cloned human kappa opioid receptor | B | 8.57 | pKi | 2.69 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1091-1095 [PMID:15686919] |
| ChEMBL | Agonistic activity at kappa opioid receptor of rabbit vas deferens | F | 8.13 | pIC50 | 7.4 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 1275-1278 |
| κ receptor in Mouse [GtoPdb: 318] [UniProtKB: P33534] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1993) 90: 6736-40 [PMID:8393575] |
| κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | - | - | - | Biochem J (1993) 295 ( Pt 3): 625-8 [PMID:8240267] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
