PL017 [Ligand Id: 1671] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL283287
  • δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL In vitro inhibitory activity against delta opioid receptor using mouse vas deferens (MVD) assay B 5.9 pIC50 1250 nM IC50 J Med Chem (1993) 36: 708-719 [PMID:8384662]
ChEMBL Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle contraction assays F 6.61 pIC50 243 nM IC50 J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assays F 7.23 pIC50 59.4 nM IC50 J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL In vitro inhibitory activity against mu opioid receptor using guinea pig ileum (GPI) assay B 7.68 pIC50 20.7 nM IC50 J Med Chem (1993) 36: 708-719 [PMID:8384662]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.2 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407];
J Pharmacol Exp Ther (1983) 227: 403-8 [PMID:6313901]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]