PL017 [Ligand Id: 1671] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL283287 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
| ChEMBL | In vitro inhibitory activity against delta opioid receptor using mouse vas deferens (MVD) assay | B | 5.9 | pIC50 | 1250 | nM | IC50 | J Med Chem (1993) 36: 708-719 [PMID:8384662] |
| ChEMBL | Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle contraction assays | F | 6.61 | pIC50 | 243 | nM | IC50 | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assays | F | 7.23 | pIC50 | 59.4 | nM | IC50 | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
| ChEMBL | In vitro inhibitory activity against mu opioid receptor using guinea pig ileum (GPI) assay | B | 7.68 | pIC50 | 20.7 | nM | IC50 | J Med Chem (1993) 36: 708-719 [PMID:8384662] |
| μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 8.2 | pKi | - | - | - |
NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]; J Pharmacol Exp Ther (1983) 227: 403-8 [PMID:6313901] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
