PL017 [Ligand Id: 1671] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL283287
  • δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL In vitro inhibitory activity against delta opioid receptor using mouse vas deferens (MVD) assay B 5.9 pIC50 1250 nM IC50 J Med Chem (1993) 36: 708-719 [PMID:8384662]
ChEMBL Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle contraction assays F 6.61 pIC50 243 nM IC50 J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assays F 7.23 pIC50 59.4 nM IC50 J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL In vitro inhibitory activity against mu opioid receptor using guinea pig ileum (GPI) assay B 7.68 pIC50 20.7 nM IC50 J Med Chem (1993) 36: 708-719 [PMID:8384662]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.2 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407];
J Pharmacol Exp Ther (1983) 227: 403-8 [PMID:6313901]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]