VER-3323 [Ligand Id: 168] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL309760 (VER-3323)
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 6.4 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (2004) 370: 114-23 [PMID:15322733]
ChEMBL Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell line B 6.45 pKi 351 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader F 6.14 pEC50 719 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line B 7.34 pKi 46 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
GtoPdb - - 7.5 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (2004) 370: 114-23 [PMID:15322733]
ChEMBL Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader F 7.96 pEC50 11 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell line B 7.62 pKi 24 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
GtoPdb - - 8.2 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (2004) 370: 114-23 [PMID:15322733]
ChEMBL Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader F 7.36 pEC50 44 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]