ChEMBL ligand: CHEMBL559569 (SB-612111)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]DAMGO from recombinant human mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method	B	7.24	pKi	58	nM	Ki	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Displacement of [3H]nociceptin from recombinant human nociceptin opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method	B	9.48	pKi	0.33	nM	Ki	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
GtoPdb	-	-	9.5	pKi	-	-	-	J Pharmacol Exp Ther (2004) 308: 454-61 [PMID:14593080]; J Pharmacol Exp Ther (2007) 321: 961-7 [PMID:17329552]
ChEMBL	Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter	B	9.6	pKi	0.25	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting	B	9.6	pKi	0.25	nM	Ki	J Med Chem (2011) 54: 2687-2700 [PMID:21438532]
GtoPdb	-	-	9.7	pIC50	-	-	-	J Pharmacol Exp Ther (2004) 308: 454-61 [PMID:14593080]; J Pharmacol Exp Ther (2007) 321: 961-7 [PMID:17329552]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]