2',3'-ddATP [Ligand Id: 1709] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1383 (2',3'-ddatp, 2',3'-dideoxy-atp, Ddatp, Dda-triphosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746] | ||||||||
| ChEMBL | Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis | B | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Binding affinity to HIV1 reverse transcriptase | B | 5.28 | pKd | 5300 | nM | Kd | Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885] |
| ChEMBL | Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) | B | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
| ChEMBL | Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) | B | 6.29 | pKi | 510 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
| ChEMBL | Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) | B | 6.3 | pKi | 500 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
| ChEMBL | Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay | B | 7.05 | pKi | 90 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852] |
| ChEMBL | Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay | B | 7.3 | pKi | 50 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852] |
| ChEMBL | Inhibitory constant against HIV-1 reverse transcriptase | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2005) 48: 2695-2700 [PMID:15801860] |
| P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | - | - | - | Br J Pharmacol (1997) 121: 338-44 [PMID:9154346] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
