2',3'-ddATP [Ligand Id: 1709] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1383 (Ddatp)
  • DNA polymerase beta in Human [ChEMBL: CHEMBL2392] [UniProtKB: P06746]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1383_lig_chart_1 DNA polymerase beta Human
There should be some charts here, you may need to enable JavaScript!
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
  • 6.3
2 CHEMBL1383_lig_chart_2 Human immunodeficiency virus type 1 reverse transcriptase Human immunodeficiency virus 1
There should be some charts here, you may need to enable JavaScript!
  • Reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8]
  • This target only has 1 pki data point
  • 7.05
3 CHEMBL1383_lig_chart_3 Reverse transcriptase Human immunodeficiency virus 1
There should be some charts here, you may need to enable JavaScript!
  • Reverse transcriptase protein in Human immunodeficiency virus 1 [ChEMBL: CHEMBL4296301] [UniProtKB: Q9WJQ2]
  • This target only has 1 pki data point
  • 7.3
4 CHEMBL1383_lig_chart_4 Reverse transcriptase protein Human immunodeficiency virus 1
There should be some charts here, you may need to enable JavaScript!
  • P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
  • This target only has 0 pki data point
  • 0
5 CHEMBL1383_lig_chart_5 P2Y1 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [UniProtKB: P06746]
ChEMBL Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis B 5.08 pIC50 8400 nM IC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis B 5.08 pIC50 8400 nM IC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) B 5.92 pKi 1200 nM Ki J. Med. Chem. (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) B 6.29 pKi 510 nM Ki J. Med. Chem. (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) B 6.3 pKi 500 nM Ki J. Med. Chem. (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibitory constant against HIV-1 reverse transcriptase B 7.7 pKi 20 nM Ki J. Med. Chem. (2005) 48: 2695-2700 [PMID:15801860]
Reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366516] [UniProtKB: Q9WKE8]
ChEMBL Binding affinity to HIV1 reverse transcriptase B 5.28 pKd 5300 nM Kd Antimicrob. Agents Chemother. (2009) 53: 3715-3719 [PMID:19596885]
ChEMBL Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay B 7.05 pKi 90 nM Ki Antimicrob. Agents Chemother. (2007) 51: 2911-2919 [PMID:17517852]
Reverse transcriptase protein in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296301] [UniProtKB: Q9WJQ2]
ChEMBL Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay B 7.3 pKi 50 nM Ki Antimicrob. Agents Chemother. (2007) 51: 2911-2919 [PMID:17517852]
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 8 pIC50 - - - Br J Pharmacol (1997) 121: 338-44 [PMID:9154346]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]