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ChEMBL ligand: CHEMBL1383 (2',3'-ddatp, 2',3'-dideoxy-atp, Ddatp, Dda-triphosphate) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746] | ||||||||
ChEMBL | Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis | B | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Binding affinity to HIV1 reverse transcriptase | B | 5.28 | pKd | 5300 | nM | Kd | Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885] |
ChEMBL | Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) | B | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
ChEMBL | Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) | B | 6.29 | pKi | 510 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
ChEMBL | Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) | B | 6.3 | pKi | 500 | nM | Ki | J Med Chem (2003) 46: 4799-4802 [PMID:14561099] |
ChEMBL | Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay | B | 7.05 | pKi | 90 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852] |
ChEMBL | Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay | B | 7.3 | pKi | 50 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852] |
ChEMBL | Inhibitory constant against HIV-1 reverse transcriptase | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2005) 48: 2695-2700 [PMID:15801860] |
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
GtoPdb | - | - | 8 | pIC50 | - | - | - | Br J Pharmacol (1997) 121: 338-44 [PMID:9154346] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]