2',3'-ddATP [Ligand Id: 1709] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1383 (2',3'-ddatp, 2',3'-dideoxy-atp, Ddatp, Dda-triphosphate)
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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  • P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746]
ChEMBL Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis B 5.08 pIC50 8400 nM IC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Binding affinity to HIV1 reverse transcriptase B 5.28 pKd 5300 nM Kd Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885]
ChEMBL Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) B 5.92 pKi 1200 nM Ki J Med Chem (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) B 6.29 pKi 510 nM Ki J Med Chem (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) B 6.3 pKi 500 nM Ki J Med Chem (2003) 46: 4799-4802 [PMID:14561099]
ChEMBL Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay B 7.05 pKi 90 nM Ki Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852]
ChEMBL Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay B 7.3 pKi 50 nM Ki Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852]
ChEMBL Inhibitory constant against HIV-1 reverse transcriptase B 7.7 pKi 20 nM Ki J Med Chem (2005) 48: 2695-2700 [PMID:15801860]
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 8 pIC50 - - - Br J Pharmacol (1997) 121: 338-44 [PMID:9154346]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]