ATP [Ligand Id: 1713] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL14249 (Adenosine 5'-triphosphoric acid, Adenosine triphosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Adenylate kinase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2376] [UniProtKB: P29410] | ||||||||
| ChEMBL | Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP, non competitive inhibition | B | 4.05 | pKi | 90000 | nM | Ki | J Med Chem (1982) 25: 1179-1184 [PMID:6292418] |
| TNF receptor associated protein 1/Heat shock protein 75 kDa, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075132] [GtoPdb: 2909] [UniProtKB: Q12931] | ||||||||
| ChEMBL | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from recombinant human Trap-1 after 24 hrs by fluorescence polarization assay | B | 4.5 | pIC50 | 31303 | nM | IC50 | J Med Chem (2013) 56: 6803-6818 [PMID:23965125] |
| Heat shock protein 90 beta in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4748] [UniProtKB: P41148] | ||||||||
| ChEMBL | Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from dog Grp94 after 24 hrs by fluorescence polarization assay | B | 5.49 | pIC50 | 3241 | nM | IC50 | J Med Chem (2013) 56: 6803-6818 [PMID:23965125] |
| ChEMBL | Inhibition of BODIPY-AG binding to dog Grp94 | B | 4.72 | pEC50 | 19000 | nM | EC50 | J Med Chem (2006) 49: 4606-4615 [PMID:16854066] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Displacement of [8-3H]ATP from human recombinant MK2 (41-364) by scintillation proximity assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 330-333 [PMID:19919896] |
| ChEMBL | Displacement of [8-3H]ATP from human recombinant MK2 (36-400) by scintillation proximity assay | B | 5.2 | pIC50 | 6300 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 330-333 [PMID:19919896] |
| ChEMBL | Inhibition of human recombinant phospho-MK2 (36-400) by HTRF assay | B | 5.55 | pIC50 | 2800 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 330-333 [PMID:19919896] |
| mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
| ChEMBL | Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 residues) expressed in baculovirus infected sf9 cells by SPR assay | B | 5.55 | pKd | 2800 | nM | Kd | Bioorg Med Chem Lett (2017) 27: 1031-1036 [PMID:28109791] |
| P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575] | ||||||||
| GtoPdb | - | - | 7.25 | pEC50 | 56 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) | F | 7.25 | pEC50 | 56 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2X2/P2X purinoceptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653] | ||||||||
| GtoPdb | - | - | 5.85 | pEC50 | 1400 | nM | EC50 | Purinergic Signal (2009) 5: 75-89 [PMID:18600475] |
| ChEMBL | Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes | F | 5.85 | pEC50 | 1400 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373] | ||||||||
| ChEMBL | Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) | F | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| GtoPdb | - | - | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571] | ||||||||
| GtoPdb | - | - | 5.9 | pEC50 | 1259 | nM | EC50 | Br J Pharmacol (2000) 129: 388-94 [PMID:10694247] |
| ChEMBL | Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincubated for 30 mins before ATP treatment by Fluo-4 AM fluorescence method | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
| GtoPdb | - | - | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4) | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2X4/P2X purinoceptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176849] [GtoPdb: 481] [UniProtKB: Q9JJX6] | ||||||||
| GtoPdb | - | - | 5.6 | pEC50 | 2511 | nM | EC50 | Br J Pharmacol (2000) 129: 388-94 [PMID:10694247] |
| GtoPdb | - | - | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Antagonist activity at mouse P2X4 receptor by cell-based calcium influx assay | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
| P2X4/P2X purinoceptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2818] [GtoPdb: 481] [UniProtKB: P51577] | ||||||||
| GtoPdb | - | - | 5.3 | pEC50 | 5011 | nM | EC50 | Br J Pharmacol (2000) 129: 388-94 [PMID:10694247] |
| ChEMBL | Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Antagonist activity at rat P2X4 receptor by cell-based calcium influx assay | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
| P2X5/P2X purinoceptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2495] [GtoPdb: 482] [UniProtKB: P51578] | ||||||||
| GtoPdb | - | - | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5) | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2X6/P2X purinoceptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2122] [GtoPdb: 483] [UniProtKB: P51579] | ||||||||
| GtoPdb | - | - | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 ) | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
| ChEMBL | Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes | F | 5.2 | pEC50 | 6353 | nM | EC50 | J Med Chem (1999) 42: 3636-3646 [PMID:10479295] |
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes | F | 5.55 | pEC50 | 2800 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes | B | 5.55 | pEC50 | 2800 | nM | EC50 | J Med Chem (2002) 45: 2090-2100 [PMID:11985476] |
| P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Mol Pharmacol (1998) 53: 727-33 [PMID:9547364] |
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - |
Br J Pharmacol (1997) 121: 338-44 [PMID:9154346]; Mol Pharmacol (2002) 62: 1249-57 [PMID:12391289] |
| ChEMBL | Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor | B | 5.82 | pEC50 | 1500 | nM | EC50 | J Med Chem (2002) 45: 2090-2100 [PMID:11985476] |
| ChEMBL | Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay | F | 6.07 | pEC50 | 850 | nM | EC50 | J Med Chem (2013) 56: 4938-4952 [PMID:23751098] |
| ChEMBL | Agonist activity at human P2Y1 receptor expressed in human 1321N1 cells assessed as increase of intracellular calcium level after 30 mins using fura-2 AM by fluorescence assay | F | 6.07 | pEC50 | 850 | nM | EC50 | J Med Chem (2014) 57: 4677-4691 [PMID:24846781] |
| ChEMBL | Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay | F | 6.07 | pEC50 | 850 | nM | EC50 | J Med Chem (2015) 58: 8427-8443 [PMID:26447940] |
| ChEMBL | Agonist activity at P2Y1 receptor expressed in human HEK293 cells | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2010) 53: 2472-2481 [PMID:20175517] |
| ChEMBL | Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis | F | 6.82 | pEC50 | 150 | nM | EC50 | J Med Chem (2010) 53: 8485-8497 [PMID:21090681] |
| P2Y1 receptor/Purinergic receptor P2Y1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2497] [GtoPdb: 323] [UniProtKB: P49651] | ||||||||
| ChEMBL | Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells | F | 6.23 | pEC50 | 590 | nM | EC50 | J Med Chem (2004) 47: 4405-4416 [PMID:15317453] |
| ChEMBL | Agonist activity at rat P2Y1R expressed in HEK293 cells assessed as release of intracellular calcium by fluorescence based assay | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2012) 55: 7623-7635 [PMID:22873688] |
| P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
| ChEMBL | Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11 | F | 4.76 | pEC50 | 17300 | nM | EC50 | J Med Chem (2002) 45: 2090-2100 [PMID:11985476] |
| ChEMBL | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) | F | 4.77 | pEC50 | 17000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay | F | 5.17 | pEC50 | 6700 | nM | EC50 | J Med Chem (2013) 56: 4938-4952 [PMID:23751098] |
| ChEMBL | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay | F | 5.17 | pEC50 | 6700 | nM | EC50 | J Med Chem (2015) 58: 8427-8443 [PMID:26447940] |
| ChEMBL | Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis | F | 5.48 | pEC50 | 3300 | nM | EC50 | J Med Chem (2010) 53: 8485-8497 [PMID:21090681] |
| GtoPdb | - | - | 5.6 | pEC50 | - | - | EC50 |
Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]; Mol Pharmacol (2003) 63: 1356-63 [PMID:12761346]; J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4] | ||||||||
| ChEMBL | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) | F | 5.5 | pEC50 | 3190 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R272A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 4.93 | pEC50 | 11700 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor C278S mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y118A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.52 | pEC50 | 299 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A_R180A double mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.62 | pEC50 | 239 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R180A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.63 | pEC50 | 237 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) | F | 6.64 | pEC50 | 230 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at P2Y2 receptor (unknown origin) | F | 6.64 | pEC50 | 230 | nM | EC50 | Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895] |
| ChEMBL | Agonist activity at P2Y2 receptor in BEA cells (unknown origin) | F | 6.7 | pEC50 | 200 | nM | EC50 | Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895] |
| ChEMBL | Agonist activity at P2Y2 receptor in human CF/T43 cells | F | 6.7 | pEC50 | 200 | nM | EC50 | Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.74 | pEC50 | 183 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at P2Y2 receptor in NG108-15 cells (unknown origin) | F | 6.74 | pEC50 | 180 | nM | EC50 | Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y198A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.92 | pEC50 | 120 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R194H mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 6.95 | pEC50 | 111 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged wild type 3 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 7.02 | pEC50 | 95.8 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 2 | F | 7.07 | pEC50 | 85 | nM | EC50 | J Med Chem (2002) 45: 2090-2100 [PMID:11985476] |
| ChEMBL | Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosphate production by scintillation proximity assay | F | 7.07 | pEC50 | 85 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 3002-3005 [PMID:19419868] |
| ChEMBL | Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C | F | 7.07 | pEC50 | 85 | nM | EC50 | J Med Chem (2007) 50: 1166-1176 [PMID:17302398] |
| GtoPdb | - | - | 7.1 | pEC50 | - | - | EC50 |
Br J Pharmacol (1995) 116: 1619-27 [PMID:8564228]; J Med Chem (2002) 45: 208-18 [PMID:11754592]; J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 7.2 | pEC50 | 63.1 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| ChEMBL | Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y114A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level | F | 7.52 | pEC50 | 30.1 | nM | EC50 | J Med Chem (2009) 52: 2762-2775 [PMID:19419204] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
| GtoPdb | - | - | 6.2 | pKd | - | - | - | Mol Pharmacol (2000) 57: 926-31 [PMID:10779375] |
| ChEMBL | The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4) | F | 4.37 | pEC50 | 43000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| GtoPdb | - | - | 5.37 | pEC50 | 4300 | nM | EC50 | Biochim Biophys Acta (2011) 1812: 982-94 [PMID:21193033] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2124] [GtoPdb: 325] [UniProtKB: O35811] | ||||||||
| ChEMBL | The compound was evaluated for agonist activity against phospholipase C coupled recombinant rat P2Y purinoceptor 4 (P2Y4) | F | 5.74 | pEC50 | 1800 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| GtoPdb | - | - | 6.3 | pEC50 | - | - | EC50 |
Br J Pharmacol (1998) 124: 428-30 [PMID:9647463]; Mol Pharmacol (2000) 57: 926-31 [PMID:10779375]; J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172] | ||||||||
| ChEMBL | Binding affinity against Purine Nucleoside Phosphatase | B | 7.16 | pKd | -7.16 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Binding affinity to wild type 6XHis-tagged human JAK2 JH2 domain (513 to 827 residues) expressed in baculovirus infected Sf9 cells by MANT-ATP binding assay | B | 5.89 | pKd | 1300 | nM | Kd | J Med Chem (2020) 63: 5324-5340 [PMID:32329617] |
| ChEMBL | Binding affinity to 6XHis-tagged human JAK2 JH2 domain V617F mutant (513 to 827 residues) expressed in baculovirus infected Sf9 cells by MANT-ATP binding assay | B | 5.89 | pKd | 1300 | nM | Kd | J Med Chem (2020) 63: 5324-5340 [PMID:32329617] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | - | - | 7.43 | pEC50 | 37 | nM | EC50 | Purinergic Signal (2011) 7: 463-8 [PMID:21773766] |
| P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | Mol Pharmacol (2003) 64: 104-12 [PMID:12815166] |
| P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572] | ||||||||
| GtoPdb | - | - | 3.11 | pEC50 | 780000 | nM | EC50 | J Med Chem (2002) 45: 4057-93 [PMID:12213051] |
| TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
| GtoPdb | - | - | 4.9 | pIC50 | - | - | - | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| GtoPdb | - | - | 5.8 | pIC50 | - | - | - | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| TRPM4 in Mouse [GtoPdb: 496] [UniProtKB: Q7TN37] | ||||||||
| GtoPdb | - | - | 6.1 | pIC50 | - | - | - | Cell Calcium (2005) 37: 267-78 [PMID:15670874] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
