CTP [Ligand Id: 1741] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL223533 (Cystetine Triphosphate)
  • Glucose-1-phosphate cytidylyltransferase in Salmonella typhi [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucose-1-phosphate cytidylyltransferase in Salmonella typhi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
ChEMBL Binding affinity to Salmonella typhi glucose-1-phosphate cytidylyl-transferase assessed as dissociation constant by spectrophotometry B 4.46 pKi 35000 nM Ki J. Med. Chem. (2015) 58: 9063-9088 [PMID:26230724]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as [3H]-inositol phosphate accumulation measured after 90 mins by anion exchange chromatographic method F 4.42 pEC50 37780 nM EC50 Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895]
P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
GtoPdb - - 5.1 pEC50 - - - Mol. Pharmacol. (2000) 57: 926-31 [PMID:10779375]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]