CTP [Ligand Id: 1741] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL223533 (Cystetine Triphosphate)
  • Glucose-1-phosphate cytidylyltransferase in Salmonella typhi [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucose-1-phosphate cytidylyltransferase in Salmonella typhi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
ChEMBL Binding affinity to Salmonella typhi glucose-1-phosphate cytidylyl-transferase assessed as dissociation constant by spectrophotometry B 4.46 pKi 35000 nM Ki J Med Chem (2015) 58: 9063-9088 [PMID:26230724]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as [3H]-inositol phosphate accumulation measured after 90 mins by anion exchange chromatographic method F 4.42 pEC50 37780 nM EC50 Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895]
P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
GtoPdb - - 5.1 pEC50 - - - Mol Pharmacol (2000) 57: 926-31 [PMID:10779375]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]