CTP [Ligand Id: 1741] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL223533 (Cystetine Triphosphate)
  • Glucose-1-phosphate cytidylyltransferase in Salmonella typhi [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucose-1-phosphate cytidylyltransferase in Salmonella typhi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745591] [UniProtKB: Q8Z5I4]
ChEMBL Binding affinity to Salmonella typhi glucose-1-phosphate cytidylyl-transferase assessed as dissociation constant by spectrophotometry B 4.46 pKi 35000 nM Ki J Med Chem (2015) 58: 9063-9088 [PMID:26230724]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as [3H]-inositol phosphate accumulation measured after 90 mins by anion exchange chromatographic method F 4.42 pEC50 37780 nM EC50 Bioorg Med Chem (2018) 26: 366-375 [PMID:29254895]
P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
GtoPdb - - 5.1 pEC50 - - - Mol Pharmacol (2000) 57: 926-31 [PMID:10779375]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]