UDP-glucose [Ligand Id: 1783] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL375951 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y14 receptor/P2Y purinoceptor 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
| GtoPdb | - | - | 7.1 | pIC50 | - | - | - | J Pharmacol Exp Ther (2009) 330: 162-8 [PMID:19339661] |
| ChEMBL | Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta | B | 3.4 | pEC50 | 400000 | nM | EC50 | Bioorg Med Chem (2015) 23: 4056-4064 [PMID:25868749] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production | F | 6.4 | pEC50 | 400 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC | F | 6.45 | pEC50 | 354 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 761-766 [PMID:17088057] |
| ChEMBL | Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis | F | 6.46 | pEC50 | 350 | nM | EC50 | J Med Chem (2007) 50: 2030-2039 [PMID:17407275] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in human COS7 cells | F | 6.58 | pEC50 | 261 | nM | EC50 | Bioorg Med Chem (2009) 17: 5298-5311 [PMID:19502066] |
| P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6] | ||||||||
| GtoPdb | - | - | 7.7 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
| P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
| GtoPdb | - | - | 7.6 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
| P2Y2 receptor/P2Y purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells | F | 5 | pEC50 | 10000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5298-5311 [PMID:19502066] |
| P2Y6 receptor/P2Y purinoceptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production | F | 5.8 | pEC50 | 1600 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 9.52 | pEC50 | 0.3 | nM | EC50 |
Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890]; EMBO J (2006) 25: 4615-27 [PMID:16990797] |
| GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
| GtoPdb | - | - | 7.26 | pEC50 | 55 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
