UDP-glucose [Ligand Id: 1783] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL375951 (UDPG, Uridine Diphosphate Glucose, 5'-Diphosphoglucose, Uridine-5'-Diphosphoglucose, Udp-Glucose)
  • P2Y14 receptor/Purinergic receptor P2Y14 in Human [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391]
  • P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6]
  • P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881]
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  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
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  • GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
  • GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391]
GtoPdb - - 7.1 pIC50 - - - J Pharmacol Exp Ther (2009) 330: 162-8 [PMID:19339661]
ChEMBL Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production F 6.4 pEC50 400 nM EC50 J. Med. Chem. (2010) 53: 471-480 [PMID:19902968]
ChEMBL Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC F 6.45 pEC50 354 nM EC50 Bioorg. Med. Chem. Lett. (2007) 17: 761-766 [PMID:17088057]
ChEMBL Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis F 6.46 pEC50 350 nM EC50 J. Med. Chem. (2007) 50: 2030-2039 [PMID:17407275]
ChEMBL Agonist activity at human P2Y14 receptor expressed in human COS7 cells F 6.58 pEC50 261 nM EC50 Bioorg. Med. Chem. (2009) 17: 5298-5311 [PMID:19502066]
P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6]
GtoPdb - - 7.7 pEC50 - - - Genomics (2001) 78: 124-8 [PMID:11735218]
P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881]
GtoPdb - - 7.6 pEC50 - - - Genomics (2001) 78: 124-8 [PMID:11735218]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells F 5 pEC50 10000 nM EC50 Bioorg. Med. Chem. (2009) 17: 5298-5311 [PMID:19502066]
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
ChEMBL Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production F 5.8 pEC50 1600 nM EC50 J. Med. Chem. (2010) 53: 471-480 [PMID:19902968]
GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
GtoPdb [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. - 9.52 pEC50 0.3 nM EC50 Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890];
EMBO J (2006) 25: 4615-27 [PMID:16990797]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb - - 7.26 pEC50 55 nM EC50 PLoS ONE (2008) 3: e3579 [PMID:18974869]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]