UDP-glucuronic acid [Ligand Id: 1784] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL228057 (Uridine-5'-Diphosphoglucuronic Acid)
  • P2Y14 receptor/Purinergic receptor P2Y14 in Human [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391]
  • P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6]
  • P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391]
ChEMBL Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis F 6.43 pEC50 370 nM EC50 J. Med. Chem. (2007) 50: 2030-2039 [PMID:17407275]
ChEMBL Agonist activity at human P2Y14 receptor expressed in human COS7 cells F 6.43 pEC50 370 nM EC50 Bioorg. Med. Chem. (2009) 17: 5298-5311 [PMID:19502066]
GtoPdb - - 7.2 pEC50 - - - J. Pharmacol. Exp. Ther. (2009) 330: 162-8 [PMID:19339661]
P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6]
GtoPdb - - 7.2 pEC50 - - - Genomics (2001) 78: 124-8 [PMID:11735218]
P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881]
GtoPdb - - 7 pEC50 - - - Genomics (2001) 78: 124-8 [PMID:11735218]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]