ABT-491 [Ligand Id: 1850] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL369225
  • PAF receptor/Platelet activating factor receptor in Human [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
  • Platelet activating factor receptor in Guinea pig [ChEMBL: CHEMBL5136] [UniProtKB: P21556]
  • 8.87
1 CHEMBL369225_lig_chart_1 Platelet activating factor receptor HumanGuinea pig
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAF receptor/Platelet activating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
GtoPdb - - 9.2 pKi - - - Eur J Pharmacol (1997) 325: 69-80 [PMID:9151941]
ChEMBL The compound was evaluated for its binding affinity against PAF receptor in human platelet B 9.24 pKi 0.57 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]
Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556]
ChEMBL The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet B 8.74 pKi 1.8 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]
ChEMBL Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes B 9 pKi 1 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]