ABT-491 [Ligand Id: 1850] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL369225
  • PAF receptor/Platelet activating factor receptor in Human [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
  • Platelet activating factor receptor in Guinea pig [ChEMBL: CHEMBL5136] [UniProtKB: P21556]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAF receptor/Platelet activating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
GtoPdb - - 9.2 pKi - - - Eur J Pharmacol (1997) 325: 69-80 [PMID:9151941]
ChEMBL The compound was evaluated for its binding affinity against PAF receptor in human platelet B 9.24 pKi 0.57 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]
Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556]
ChEMBL The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet B 8.74 pKi 1.8 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]
ChEMBL Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes B 9 pKi 1 nM Ki J. Med. Chem. (1998) 41: 74-95 [PMID:9438024]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]