PGD2 [Ligand Id: 1881] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1235252
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
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  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
  • DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
  • DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
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  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
  • DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
  • DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
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  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
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  • EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
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  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
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  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
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  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
  • FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.42 pKi 38 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.01 pKi 98 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.35 pKi 45 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 9.2 pKi - - - Eur J Pharmacol (1999) 377: 101-15 [PMID:10448933];
J Biol Chem (1995) 270: 18910-6 [PMID:7642548];
Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725];
Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]
DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
GtoPdb - - 7.7 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
GtoPdb - - 7.6 pKi - - - Eur J Pharmacol (1999) 377: 101-15 [PMID:10448933]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 8.6 pKi - - - Br J Pharmacol (2002) 137: 1163-72 [PMID:12466225];
Eur J Pharmacol (2005) 524: 30-7 [PMID:16256979]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb - - 7.5 pKi - - - J Pharmacol Exp Ther (2003) 306: 463-70 [PMID:12721327];
J Biol Chem (2005) 280: 32442-32451 [PMID:16030019]
DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
GtoPdb - - 8.2 pIC50 - - - J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488]
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.7 pKi - - - J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 5.2 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 5 pKi - - - Mol Pharmacol (1999) 56: 545-51 [PMID:10462542]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 6.55 pKi 280 nM Ki Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 5.9 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 8.89 pKi 1.3 nM Ki Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 7.89 pEC50 13 nM EC50 Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 9 pKi 1 nM Ki Mol Pharmacol (1999) 56: 545-51 [PMID:10462542];
Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
GtoPdb - - 8.77 pEC50 1.7 nM EC50 J Pharmacol Exp Ther (2009) 331: 297-307 [PMID:19584306]
EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb - - 5.9 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 7.7 pKi - - - Biochem J (2003) 371: 443-9 [PMID:12519077]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb - - 7.3 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]