PGD2 [Ligand Id: 1881] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1235252
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
1 CHEMBL1235252_lig_chart_1 Solute carrier organic anion transporter family member 2A1 HumanMouseRat
There should be some charts here, you may need to enable JavaScript!
  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
  • DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
  • DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
2 CHEMBL1235252_lig_chart_2 DP1 receptor HumanMouseRat
There should be some charts here, you may need to enable JavaScript!
  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
  • DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
  • DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
3 CHEMBL1235252_lig_chart_3 DP2 receptor HumanMouseRat
There should be some charts here, you may need to enable JavaScript!
  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
4 CHEMBL1235252_lig_chart_4 EP1 receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
5 CHEMBL1235252_lig_chart_5 EP2 receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
6 CHEMBL1235252_lig_chart_6 EP3 receptor MouseRat
There should be some charts here, you may need to enable JavaScript!
  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
7 CHEMBL1235252_lig_chart_7 EP4 receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
  • FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
8 CHEMBL1235252_lig_chart_8 FP receptor HumanMouse
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.42 pKi 38 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.01 pKi 98 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.35 pKi 45 nM Ki Am. J. Physiol. (1999) 277: R734-R741 [PMID:10484490]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 9.2 pKi - - - Eur. J. Pharmacol. (1999) 377: 101-15 [PMID:10448933];
J. Biol. Chem. (1995) 270: 18910-6 [PMID:7642548];
Br. J. Pharmacol. (1998) 123: 1317-24 [PMID:9579725];
Br. J. Pharmacol. (2006) 148: 326-39 [PMID:16604093]
DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
GtoPdb - - 7.7 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
GtoPdb - - 7.6 pKi - - - Eur. J. Pharmacol. (1999) 377: 101-15 [PMID:10448933]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 8.6 pKi - - - Br. J. Pharmacol. (2002) 137: 1163-72 [PMID:12466225];
Eur. J. Pharmacol. (2005) 524: 30-7 [PMID:16256979]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb - - 7.5 pKi - - - J. Pharmacol. Exp. Ther. (2003) 306: 463-70 [PMID:12721327];
J Biol Chem (2005) 280: 32442-32451 [PMID:16030019]
DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
GtoPdb - - 8.2 pIC50 - - - J. Pharmacol. Exp. Ther. (2003) 307: 518-25 [PMID:12975488]
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.7 pKi - - - J. Pharm. Pharmacol. (2002) 54: 539-47 [PMID:11999132]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 5.2 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 5 pKi - - - Mol. Pharmacol. (1999) 56: 545-51 [PMID:10462542]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 5.3 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 6.55 pKi 280 nM Ki Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 5.9 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 8.89 pKi 1.3 nM Ki Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 7.89 pEC50 13 nM EC50 Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 9 pKi 1 nM Ki Mol. Pharmacol. (1999) 56: 545-51 [PMID:10462542];
Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
GtoPdb - - 8.77 pEC50 1.7 nM EC50 J. Pharmacol. Exp. Ther. (2009) 331: 297-307 [PMID:19584306]
EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb - - 5.9 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 7.7 pKi - - - Biochem. J. (2003) 371: 443-9 [PMID:12519077]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb - - 7.3 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]