PGI2 [Ligand Id: 1915] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1139 (ACT-385781A, Epoprostenol, Flolan, Pgi2, PG-I2, Pgx, Prostacyclin, Prostaglandin i2, Prostaglandin x, U-53217, U-53,217)
  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
There should be some charts here, you may need to enable JavaScript!
  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
There should be some charts here, you may need to enable JavaScript!
  • IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.8 pKi - - - J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 5.1 pKi - - - Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 7.8 pKi 15.85 nM Ki J Clin Invest (1979) 63: 215-20 [PMID:372237]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]