PGI2 [Ligand Id: 1915] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1139 (ACT-385781A, Epoprostenol, Flolan, Pgi2, PG-I2, Pgx, Prostacyclin, Prostaglandin i2, Prostaglandin x, U-53217, U-53,217)
  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
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  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
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  • IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.8 pKi - - - J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 5.1 pKi - - - Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 7.8 pKi 15.85 nM Ki J Clin Invest (1979) 63: 215-20 [PMID:372237]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]