11-deoxy-PGE1 [Ligand Id: 1925] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3246389
  • EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
  • 7.5
1 CHEMBL3246389_lig_chart_1 EP2 receptor MouseRat
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  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
  • 8.5
2 CHEMBL3246389_lig_chart_2 EP3 receptor MouseRat
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  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240]
  • 7.6
3 CHEMBL3246389_lig_chart_3 EP4 receptor HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
GtoPdb - - 7.3 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 7.5 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 8.82 pKi 1.5 nM Ki Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 8.5 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 8.9 pKi - - - Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
GtoPdb - - 9.33 pEC50 0.47 nM EC50 J Pharmacol Exp Ther (2009) 331: 297-307 [PMID:19584306]
EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240]
GtoPdb - - 7.6 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]