rivenprost [Ligand Id: 1930] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL303960 ((-)-ono-4819, ONO-4819, Rivenprost) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| EP3 receptor/Prostanoid EP3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557] | ||||||||
| GtoPdb | - | - | 7.25 | pKi | 56 | nM | Ki | Proc Natl Acad Sci USA (2002) 99: 4580-5 [PMID:11917107] |
| ChEMBL | Binding affinity to mouse EP3 receptor by competitive binding assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| EP4 receptor/Prostanoid EP4 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2489] [GtoPdb: 343] [UniProtKB: P32240] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Proc Natl Acad Sci USA (2002) 99: 4580-5 [PMID:11917107] |
| ChEMBL | Agonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP production | F | 8.8 | pEC50 | 1.6 | nM | EC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053] | ||||||||
| GtoPdb | - | - | 6.2 | pKi | - | - | - | Proc Natl Acad Sci USA (2002) 99: 4580-5 [PMID:11917107] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
