I-BOP [Ligand Id: 1938] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2113346
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
  • TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987]
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  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
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  • FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
GtoPdb - - 9.32 pKd 0.48 nM Kd J. Biol. Chem. (1991) 266: 13752-8 [PMID:1830308]
ChEMBL Binding affinity towards Thromboxane A2 receptor/Prostaglandin receptor in human platelet membranes using [125I]- as the radioligand B 7.3 pIC50 50 nM IC50 J. Med. Chem. (1991) 34: 1511-1514 [PMID:1826745]
TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987]
GtoPdb - - 9.3 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 7 pKi 100 nM Ki Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb - - 7 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]