latanoprost (free acid form) [Ligand Id: 1960] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1050 (Latanoprost acid, Latonoprost acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| Prostanoid FP receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4820] [UniProtKB: P37289] | ||||||||
| ChEMBL | Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane | B | 7.01 | pKi | 98 | nM | Ki | Bioorg Med Chem (2009) 17: 576-584 [PMID:19101156] |
| FP receptor/Prostanoid FP receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5000] [GtoPdb: 344] [UniProtKB: P43117] | ||||||||
| ChEMBL | Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting | F | 7.5 | pEC50 | 31.7 | nM | EC50 | Bioorg Med Chem (2009) 17: 576-584 [PMID:19101156] |
| ChEMBL | Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR | F | 8.2 | pEC50 | 6.31 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571] |
| OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PGE1 uptake (PGE1: 0.0004 uM) in PGT-expressing HeLa cells | F | 6.83 | pKi | 149 | nM | Ki | Exp Eye Res (2002) 74: 41-49 [PMID:11878817] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
