latanoprost (isopropyl ester) [Ligand Id: 1961] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1051 (Latanoprost, Latanoprost (isopropyl ester), Monopost, PHXA-41, PHXA41, T-2345, T2345, XA-41, XA41, Xalatan, Xelpros)
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
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  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
ChEMBL TP_TRANSPORTER: inhibition of PGE1 uptake (PGE1: 0.0004 uM) in PGT-expressing HeLa cells F 5 pKi >10000 nM Ki Exp Eye Res (2002) 74: 41-49 [PMID:11878817]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 6.3 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]