SRA880 [Ligand Id: 2030] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL251541 (Obelin)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • SST1 receptor/Somatostatin receptor 1 in Human [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
  • SST1 receptor/Somatostatin receptor 1 in Rat [ChEMBL: CHEMBL4652] [GtoPdb: 355] [UniProtKB: P28646]
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  • SST2 receptor/Somatostatin receptor 2 in Human [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
  • SST2 receptor/Somatostatin receptor 2 in Rat [ChEMBL: CHEMBL2978] [GtoPdb: 356] [UniProtKB: P30680]
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  • SST3 receptor/Somatostatin receptor 3 in Human [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
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  • SST4 receptor/Somatostatin receptor 4 in Human [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
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  • SST5 receptor/Somatostatin receptor 5 in Human [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to human adrenergic beta-1 receptor B 6.65 pKd 223.87 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity to human dopamine D4 receptor B 8.3 pKd 5.01 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Binding affinity to dopamine D4 receptor B 8.3 pKd 5.01 nM Kd Bioorg Med Chem Lett (2009) 19: 1305-1309 [PMID:19208473]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity to human 5HT1D receptor B 6.95 pKd 112.2 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
SST1 receptor/Somatostatin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
ChEMBL Binding affinity to human recombinant sst1 receptor B 7.99 pKd 10.23 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
GtoPdb - - 8.1 pKd - - - Neurosci Lett (2004) 361: 132-5 [PMID:15135911]
SST1 receptor/Somatostatin receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4652] [GtoPdb: 355] [UniProtKB: P28646]
ChEMBL Displacement of [125I]SRIF14 from sst1 receptor in rat brain cortex membrane B 9.15 pKd 0.71 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Displacement of [125I]SRIF14 from rat sst1 receptor from rat brain cortex membrane B 9.15 pKd 0.71 nM Kd Bioorg Med Chem Lett (2007) 17: 3988-3991 [PMID:17512199]
SST2 receptor/Somatostatin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
ChEMBL Binding affinity to human recombinant sst2 receptor B 4.44 pKd 36307.81 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
SST2 receptor/Somatostatin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2978] [GtoPdb: 356] [UniProtKB: P30680]
ChEMBL Displacement of [125I]SRIF14 from sst2 receptor in rat brain cortex membrane B 5.11 pKd 7762.47 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Displacement of [125I]SRIF14 from rat sst2 receptor from rat brain cortex membrane B 5.11 pKd 7762.47 nM Kd Bioorg Med Chem Lett (2007) 17: 3988-3991 [PMID:17512199]
SST3 receptor/Somatostatin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
ChEMBL Binding affinity to human recombinant sst3 receptor B 5.06 pKd 8709.64 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
SST4 receptor/Somatostatin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
ChEMBL Binding affinity to human recombinant sst4 receptor B 4.82 pKd 15135.61 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]
SST5 receptor/Somatostatin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
ChEMBL Binding affinity to human recombinant sst5 receptor B 5.75 pKd 1778.28 nM Kd Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]