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ChEMBL ligand: CHEMBL251541 (Obelin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
ChEMBL | Binding affinity to human adrenergic beta-1 receptor | B | 6.65 | pKd | 223.87 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
ChEMBL | Binding affinity to human dopamine D4 receptor | B | 8.3 | pKd | 5.01 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
ChEMBL | Binding affinity to dopamine D4 receptor | B | 8.3 | pKd | 5.01 | nM | Kd | Bioorg Med Chem Lett (2009) 19: 1305-1309 [PMID:19208473] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
ChEMBL | Binding affinity to human 5HT1D receptor | B | 6.95 | pKd | 112.2 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
SST1 receptor/Somatostatin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872] | ||||||||
ChEMBL | Binding affinity to human recombinant sst1 receptor | B | 7.99 | pKd | 10.23 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
GtoPdb | - | - | 8.1 | pKd | - | - | - | Neurosci Lett (2004) 361: 132-5 [PMID:15135911] |
SST1 receptor/Somatostatin receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4652] [GtoPdb: 355] [UniProtKB: P28646] | ||||||||
ChEMBL | Displacement of [125I]SRIF14 from sst1 receptor in rat brain cortex membrane | B | 9.15 | pKd | 0.71 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
ChEMBL | Displacement of [125I]SRIF14 from rat sst1 receptor from rat brain cortex membrane | B | 9.15 | pKd | 0.71 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3988-3991 [PMID:17512199] |
SST2 receptor/Somatostatin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874] | ||||||||
ChEMBL | Binding affinity to human recombinant sst2 receptor | B | 4.44 | pKd | 36307.81 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
SST2 receptor/Somatostatin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2978] [GtoPdb: 356] [UniProtKB: P30680] | ||||||||
ChEMBL | Displacement of [125I]SRIF14 from sst2 receptor in rat brain cortex membrane | B | 5.11 | pKd | 7762.47 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
ChEMBL | Displacement of [125I]SRIF14 from rat sst2 receptor from rat brain cortex membrane | B | 5.11 | pKd | 7762.47 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3988-3991 [PMID:17512199] |
SST3 receptor/Somatostatin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745] | ||||||||
ChEMBL | Binding affinity to human recombinant sst3 receptor | B | 5.06 | pKd | 8709.64 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
SST4 receptor/Somatostatin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391] | ||||||||
ChEMBL | Binding affinity to human recombinant sst4 receptor | B | 4.82 | pKd | 15135.61 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
SST5 receptor/Somatostatin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346] | ||||||||
ChEMBL | Binding affinity to human recombinant sst5 receptor | B | 5.75 | pKd | 1778.28 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 3983-3987 [PMID:17507221] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]