SRA880 [Ligand Id: 2030] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL251541 (Obelin)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • SST1 receptor/Somatostatin receptor 1 in Human [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
  • SST1 receptor/Somatostatin receptor 1 in Rat [ChEMBL: CHEMBL4652] [GtoPdb: 355] [UniProtKB: P28646]
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  • SST2 receptor/Somatostatin receptor 2 in Human [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
  • SST2 receptor/Somatostatin receptor 2 in Rat [ChEMBL: CHEMBL2978] [GtoPdb: 356] [UniProtKB: P30680]
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  • SST3 receptor/Somatostatin receptor 3 in Human [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
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  • SST4 receptor/Somatostatin receptor 4 in Human [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
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  • SST5 receptor/Somatostatin receptor 5 in Human [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to human adrenergic beta-1 receptor B 6.65 pKd 223.87 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity to human dopamine D4 receptor B 8.3 pKd 5.01 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Binding affinity to dopamine D4 receptor B 8.3 pKd 5.01 nM Kd Bioorg. Med. Chem. Lett. (2009) 19: 1305-1309 [PMID:19208473]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity to human 5HT1D receptor B 6.95 pKd 112.2 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
SST1 receptor/Somatostatin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
ChEMBL Binding affinity to human recombinant sst1 receptor B 7.99 pKd 10.23 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
GtoPdb - - 8.1 pKd - - - Neurosci Lett (2004) 361: 132-5 [PMID:15135911]
SST1 receptor/Somatostatin receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4652] [GtoPdb: 355] [UniProtKB: P28646]
ChEMBL Displacement of [125I]SRIF14 from sst1 receptor in rat brain cortex membrane B 9.15 pKd 0.71 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Displacement of [125I]SRIF14 from rat sst1 receptor from rat brain cortex membrane B 9.15 pKd 0.71 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3988-3991 [PMID:17512199]
SST2 receptor/Somatostatin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
ChEMBL Binding affinity to human recombinant sst2 receptor B 4.44 pKd 36307.81 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
SST2 receptor/Somatostatin receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2978] [GtoPdb: 356] [UniProtKB: P30680]
ChEMBL Displacement of [125I]SRIF14 from sst2 receptor in rat brain cortex membrane B 5.11 pKd 7762.47 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
ChEMBL Displacement of [125I]SRIF14 from rat sst2 receptor from rat brain cortex membrane B 5.11 pKd 7762.47 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3988-3991 [PMID:17512199]
SST3 receptor/Somatostatin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
ChEMBL Binding affinity to human recombinant sst3 receptor B 5.06 pKd 8709.64 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
SST4 receptor/Somatostatin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
ChEMBL Binding affinity to human recombinant sst4 receptor B 4.82 pKd 15135.61 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]
SST5 receptor/Somatostatin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
ChEMBL Binding affinity to human recombinant sst5 receptor B 5.75 pKd 1778.28 nM Kd Bioorg. Med. Chem. Lett. (2007) 17: 3983-3987 [PMID:17507221]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]