SCH 206272 [Ligand Id: 2106] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL77023 (SCH-206272) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand | B | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 2355-2358 [PMID:12161132] |
| GtoPdb | - | - | 8.9 | pKi | - | - | - | Eur J Pharmacol (2002) 450: 191-202 [PMID:12206858] |
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| ChEMBL | Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 2355-2358 [PMID:12161132] |
| GtoPdb | - | - | 9.4 | pKi | - | - | - | Eur J Pharmacol (2002) 450: 191-202 [PMID:12206858] |
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| GtoPdb | - | - | 9.5 | pKi | - | - | - | Eur J Pharmacol (2002) 450: 191-202 [PMID:12206858] |
| ChEMBL | Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I][MePhe]-NKB as radioligand | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 2355-2358 [PMID:12161132] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
