GR 159897 [Ligand Id: 2115] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2110370 (GR-159897) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| GtoPdb | - | - | 9.5 | pKd | - | - | - |
Biochem Biophys Res Commun (1993) 191: 1172-7 [PMID:7682062]; J Med Chem (1995) 38: 3772-9 [PMID:7562907]; Eur J Pharmacol (1995) 272: 241-8 [PMID:7713168] |
| ChEMBL | Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells | B | 9.5 | pKi | 0.32 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1951-1956 |
| NK2 receptor/Neurokinin 2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4554] [GtoPdb: 361] [UniProtKB: P16610] | ||||||||
| ChEMBL | Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1951-1956 |
| Neurokinin 3 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3799] [UniProtKB: P30098] | ||||||||
| ChEMBL | Tested for inhibition of binding of [3H]senktide to Tachykinin receptor 3 in guinea pig cerebral cortex membranes | B | 4.7 | pKi | 19952.62 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1951-1956 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
