ChEMBL ligand: CHEMBL19393 (Amfetamine, (r)-, Amphetamine l-form, l-Amphetamine, Levamfetamine)
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Trace amine-associated receptor 1 in Rhesus macaque [ChEMBL: CHEMBL1926495] [UniProtKB: Q8HZ64] TA1 receptor/Trace amine-associated receptor 1 in Human [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] TA1 receptor/Trace amine-associated receptor 1 in Mouse [ChEMBL: CHEMBL4908] [GtoPdb: 364] [UniProtKB: Q923Y8] TA1 receptor/Trace amine-associated receptor 1 in Rat [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligand	B	4.33	pKi	46400	nM	Ki	J Med Chem (1991) 34: 1094-1098 [PMID:1848295]
Trace amine-associated receptor 1 in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926495] [UniProtKB: Q8HZ64]
ChEMBL	Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader	F	5.73	pEC50	1860	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0]
ChEMBL	Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method in presence of RX821002 and alprenolol	F	5.77	pEC50	1700	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay	F	5.89	pEC50	1300	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay	F	6.04	pEC50	920	nM	EC50	Bioorg Med Chem (2008) 16: 7415-7423 [PMID:18602830]
GtoPdb	-	-	6.2	pEC50	600	nM	EC50	Bioorg Med Chem (2011) 19: 7044-8 [PMID:22037049]
GtoPdb	-	-	6.6	pEC50	-	-	-	Mol Pharmacol (2008) 74: 585-594 [PMID:18524885]
ChEMBL	Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay	F	6.6	pEC50	250	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
TA1 receptor/Trace amine-associated receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4908] [GtoPdb: 364] [UniProtKB: Q923Y8]
ChEMBL	Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting	F	5.3	pEC50	4960	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.1	pEC50	785.5	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.92	pEC50	121	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.98	pEC50	104.5	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins	F	7.19	pEC50	65	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
GtoPdb	-	-	7.2	pEC50	-	-	-	J Pharmacol Exp Ther (2007) 321: 178-86 [PMID:17218486]; Genes Brain Behav (2007) 6: 628-39 [PMID:17212650]
TA1 receptor/Trace amine-associated receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
ChEMBL	Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method	F	5.85	pEC50	1400	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting	F	6.55	pEC50	280	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.67	pEC50	214.4	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay	F	6.68	pEC50	210	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
GtoPdb	-	-	6.7	pEC50	-	-	-	J Pharmacol Exp Ther (2007) 321: 178-86 [PMID:17218486]; Mol Pharmacol (2001) 60: 1181-8 [PMID:11723224]
ChEMBL	Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.77	pEC50	169.9	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	7.47	pEC50	33.9	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]