ChEMBL ligand: CHEMBL19393 (Amfetamine, (r)-, Amphetamine l-form, l-Amphetamine, Levamfetamine, Levanfetamina)
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Trace amine-associated receptor 1 in Rhesus macaque [ChEMBL: CHEMBL1926495] [UniProtKB: Q8HZ64] TA1 receptor/Trace amine-associated receptor 1 in Human [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] TA1 receptor/Trace amine-associated receptor 1 in Mouse [ChEMBL: CHEMBL4908] [GtoPdb: 364] [UniProtKB: Q923Y8] TA1 receptor/Trace amine-associated receptor 1 in Rat [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligand	B	4.33	pKi	46400	nM	Ki	J Med Chem (1991) 34: 1094-1098 [PMID:1848295]
Trace amine-associated receptor 1 in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926495] [UniProtKB: Q8HZ64]
ChEMBL	Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader	F	5.73	pEC50	1860	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0]
ChEMBL	Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method in presence of RX821002 and alprenolol	F	5.77	pEC50	1700	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay	F	5.89	pEC50	1300	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay	F	6.04	pEC50	920	nM	EC50	Bioorg Med Chem (2008) 16: 7415-7423 [PMID:18602830]
GtoPdb	-	-	6.2	pEC50	600	nM	EC50	Bioorg Med Chem (2011) 19: 7044-8 [PMID:22037049]
GtoPdb	-	-	6.6	pEC50	-	-	-	Mol Pharmacol (2008) 74: 585-594 [PMID:18524885]
ChEMBL	Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay	F	6.6	pEC50	250	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
TA1 receptor/Trace amine-associated receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4908] [GtoPdb: 364] [UniProtKB: Q923Y8]
ChEMBL	Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting	F	5.3	pEC50	4960	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.1	pEC50	785.5	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.92	pEC50	121	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.98	pEC50	104.5	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins	F	7.19	pEC50	65	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
GtoPdb	-	-	7.2	pEC50	-	-	-	J Pharmacol Exp Ther (2007) 321: 178-86 [PMID:17218486]; Genes Brain Behav (2007) 6: 628-39 [PMID:17212650]
TA1 receptor/Trace amine-associated receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
ChEMBL	Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method	F	5.85	pEC50	1400	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting	F	6.55	pEC50	280	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
ChEMBL	Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.67	pEC50	214.4	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay	F	6.68	pEC50	210	nM	EC50	Bioorg Med Chem (2011) 19: 7044-7048 [PMID:22037049]
GtoPdb	-	-	6.7	pEC50	-	-	-	J Pharmacol Exp Ther (2007) 321: 178-86 [PMID:17218486]; Mol Pharmacol (2001) 60: 1181-8 [PMID:11723224]
ChEMBL	Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	6.77	pEC50	169.9	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]
ChEMBL	Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay	F	7.47	pEC50	33.9	nM	EC50	J Med Chem (2014) 57: 378-390 [PMID:24354319]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]