Ro 25-1553 [Ligand Id: 2259] activity data from GtoPdb

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  • PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
  • PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215]
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  • VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
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  • VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
GtoPdb inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor - 6 pIC50 >1000 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor - 6 pEC50 >1000 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215]
GtoPdb inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor - 5 pIC50 >10000 nM IC50 Peptides (1997) 18: 403-8 [PMID:9145428]
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 6 pIC50 >1000 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 6.1 pIC50 800 nM IC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 7 pIC50 100 nM IC50 Peptides (1997) 18: 403-8 [PMID:9145428]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 6 pEC50 1000 nM EC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 6 pEC50 >1000 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9.52 pIC50 0.3 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347];
Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056];
Peptides (1997) 18: 403-8 [PMID:9145428]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 8.3 pEC50 5 nM EC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 8.7 pEC50 2 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.