PG 97-269 [Ligand Id: 2268] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215] | ||||||||
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 4.5 | pIC50 | 30000 | nM | IC50 | Peptides (1997) 18: 1555-60 [PMID:9437716] |
| VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] | ||||||||
| GtoPdb | inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor | - | 7.1 | pIC50 | 80 | nM | IC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor | - | 8 | pIC50 | 9.9 | nM | IC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor | - | 8.7 | pIC50 | 2 | nM | IC50 |
Peptides (1997) 18: 1555-60 [PMID:9437716]; Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8 | pIC50 | 10 | nM | IC50 | Peptides (1997) 18: 1555-60 [PMID:9437716] |
| VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 5.5 | pIC50 | 3000 | nM | IC50 | Peptides (1997) 18: 1555-60 [PMID:9437716] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 5.7 | pIC50 | 2000 | nM | IC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 5.7 | pIC50 | 2000 | nM | IC50 | Peptides (1997) 18: 1555-60 [PMID:9437716] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
