Ro 25-1392 [Ligand Id: 2276] activity data from GtoPdb

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  • VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
  • This target only has 1 pki data point
1 _lig_chart_1 VPAC1 receptor Human
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  • VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
  • This target only has 1 pki data point
2 _lig_chart_2 VPAC2 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
GtoPdb inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor - 5.5 pKi >3000 nM Ki J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 6 pEC50 >1000 nM EC50 J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
GtoPdb inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor - 8 pKi 9.6 nM Ki J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 8.5 pEC50 3 nM EC50 J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.