tubocurarine [Ligand Id: 2294] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL339427 (Tubocurarine)
  • Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
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  • MATE2/Multidrug and toxin extrusion protein 2 in Human [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
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  • Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
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  • 5-HT3AB in Human [GtoPdb: 378]
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  • 5-HT3A in Human [GtoPdb: 379]
  • 5-HT3A in Mouse [GtoPdb: 379]
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  • KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
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  • KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
  • KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
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  • KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
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  • ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay B 5.03 pIC50 9400 nM IC50 J. Med. Chem. (2013) 56: 781-795 [PMID:23241029]
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
ChEMBL Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay B 4.26 pIC50 55500 nM IC50 J. Med. Chem. (2013) 56: 781-795 [PMID:23241029]
Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
ChEMBL Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting B 5.73 pKi 1880 nM Ki J Pesticide Sci (1992) 17: 231-236
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay B 4.1 pIC50 78800 nM IC50 J. Med. Chem. (2013) 56: 781-795 [PMID:23241029]
5-HT3AB in Human [GtoPdb: 378]
GtoPdb - - 4.5 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465]
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 4.8 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465];
Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349]
5-HT3A in Mouse [GtoPdb: 379]
GtoPdb - - 7.1 pKi - - - J Neurochem (1995) 65: 104-10 [PMID:7790853];
Neuropharmacology (1998) 37: 251-7 [PMID:9680250]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb - - 4.6 pIC50 25000 nM IC50 Science (1996) 273: 1709-14 [PMID:8781233];
Br J Pharmacol (2000) 129: 627-30 [PMID:10683185];
Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb - - 5.7 pIC50 - - - FEBS Lett (2000) 469: 196-202 [PMID:10713270]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb - - 5.6 pIC50 - - - Science (1996) 273: 1709-14 [PMID:8781233];
Br J Pharmacol (2000) 129: 991-9 [PMID:10696100];
J Biol Chem (1997) 272: 23195-200 [PMID:9287325]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb - - 4.5 pIC50 - - - Neuropharmacology (2001) 40: 772-83 [PMID:11369031];
Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
GtoPdb - - 5.2 pIC50 6300 nM IC50 J Biol Chem (2003) 278: 712-7 [PMID:12381728]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]