flindokalner [Ligand Id: 2307] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL266510 (Flindokalner, Maxipost, BMS-204352)
  • KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791]
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  • Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526]
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  • Kv7.3/Voltage-gated potassium channel subunit Kv7.3 in Human [ChEMBL: CHEMBL2684] [GtoPdb: 562] [UniProtKB: O43525]
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  • Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
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  • Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791]
ChEMBL Positive modulation of Kca 1.1 (unknown origin) B 6.45 pEC50 352 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
GtoPdb - - 6.5 pEC50 - - - Nat Med (2001) 7: 471-7 [PMID:11283675]
Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526]
GtoPdb - - 5 pEC50 - - - Neuropharmacology (2001) 40: 888-98 [PMID:11378159]
ChEMBL Positive modulatory activity at voltage-gated K channel 7.2 (unknown origin) B 5.62 pEC50 2400 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
Kv7.3/Voltage-gated potassium channel subunit Kv7.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2684] [GtoPdb: 562] [UniProtKB: O43525]
ChEMBL Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin) B 5.62 pEC50 2400 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
GtoPdb - - 5 pEC50 - - - Am J Physiol, Cell Physiol (2001) 280: C859-66 [PMID:11245603]
ChEMBL Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin) B 5.62 pEC50 2400 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82]
GtoPdb - - 5.6 pEC50 - - - Eur J Pharmacol (2002) 437: 129-37 [PMID:11890900]
ChEMBL Positive modulatory activity at voltage-gated K channel 7.5 (unknown origin) B 5.62 pEC50 2400 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]