ChEMBL ligand: CHEMBL525408 (Apamin)
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952] KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Rat [ChEMBL: CHEMBL3743] [GtoPdb: 381] [UniProtKB: P70606] There should be some charts here, you may need to enable JavaScript!
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6] KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605] There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb	-	-	8.48	pIC50	3.3	nM	IC50	Br J Pharmacol (2000) 129: 627-30 [PMID:10683185]; Toxicon (2004) 43: 933-49 [PMID:15208027]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]
ChEMBL	Displacement of radiolabeled apamin from calcium-activated SK channel	B	10.85	pIC50	0.01	nM	IC50	J. Med. Chem. (2008) 51: 7094-7098 [PMID:18983139]
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3743] [GtoPdb: 381] [UniProtKB: P70606]
ChEMBL	Inhibition of rat SK Calcium channel	B	10.62	pIC50	0.02	nM	IC50	Bioorg. Med. Chem. (2010) 18: 7675-7699 [PMID:20875743]
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb	-	-	9.1	pIC50	0.8	nM	IC50	Neuropharmacology (2001) 40: 772-83 [PMID:11369031]; Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	B	9.77	pIC50	0.17	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 5694-5697 [PMID:18824351]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	B	9.77	pIC50	0.17	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 5316-5319 [PMID:18774291]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay	B	10.19	pIC50	0.06	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 5694-5697 [PMID:18824351]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay	B	10.19	pIC50	0.06	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 5316-5319 [PMID:18774291]
KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
GtoPdb	-	-	9.2	pIC50	-	-	-	Am J Physiol, Cell Physiol (2001) 280: C836-42 [PMID:11245600]; J Physiol (Lond.) (2001) 535: 323-34 [PMID:11533126]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb	-	-	9.4	pKd	0.3	nM	Kd	FEBS Lett (2000) 469: 196-202 [PMID:10713270]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb	-	-	10.2	pIC50	-	-	-	Science (1996) 273: 1709-14 [PMID:8781233]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]