UCL1684 [Ligand Id: 2320] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1178830
  • KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
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  • KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
  • KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
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  • KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
  • KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb - - 9.1 pIC50 0.8 nM IC50 Br J Pharmacol (2000) 129: 991-9 [PMID:10696100];
Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb - - 9.6 pIC50 - - - J Biol Chem (2001) 276: 12249-56 [PMID:11278890];
Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb - - 9.4 pIC50 - - - Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb - - 9 pIC50 - - - J Biol Chem (2001) 276: 12249-56 [PMID:11278890];
Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
GtoPdb - - 8.2 pIC50 - - - J Physiol (Lond.) (2001) 535: 323-34 [PMID:11533126]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]