senicapoc [Ligand Id: 2331] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL405821 (ICA-17043, PF-05416266, Senicapoc) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| ChEMBL | Inhibition of gardos channel (unknown origin) | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| ChEMBL | Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2008) 51: 976-982 [PMID:18232633] |
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | Blood (2003) 101: 2412-8 [PMID:12433690] |
| ChEMBL | Inhibition of Kca 3.1 (unknown origin) | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Protein Red in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321616] [UniProtKB: Q13123] | ||||||||
| ChEMBL | Inhibition of IK (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.1/Sodium channel protein type I alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1845] [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.1 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.2/Sodium channel protein type II alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4187] [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.2 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.3/Sodium channel protein type III alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5163] [GtoPdb: 580] [UniProtKB: Q9NY46] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.3 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.4/Sodium channel protein type IV alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2072] [GtoPdb: 581] [UniProtKB: P35499] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.4 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.7 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.6/Sodium channel protein type VIII alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5202] [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.6 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of voltage-gated K channel 1.5 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| ChEMBL | Inhibition of voltage-gated K channel 7.1 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
