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ChEMBL ligand: CHEMBL9324 (NSC-102778, NSC-156315, Tetraethylammonium cation, Tetraethylammonium ion, Tetramon) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes | F | 6.27 | pIC50 | 540 | nM | IC50 | Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes | F | 4 | pKi | 100000 | nM | Ki | J Pharmacol Exp Ther (2000) 292: 1146-1152 [PMID:10688634] |
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells | F | 4.33 | pKi | 46600 | nM | Ki | J Pharmacol Exp Ther (1998) 287: 800-805 [PMID:9808712] |
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes | F | 5.46 | pIC50 | 3500 | nM | IC50 | Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030] |
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells | F | 4.28 | pKi | 52200 | nM | Ki | J Pharmacol Exp Ther (1998) 287: 800-805 [PMID:9808712] |
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] | ||||||||
ChEMBL | Inhibition of Kv1.1 (unknown origin) | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (2017) 60: 2245-2256 [PMID:28225274] |
Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] | ||||||||
GtoPdb | - | - | 3.5 | pKd | 300000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952] | ||||||||
GtoPdb | - | - | 2.7 | pIC50 | - | - | - | Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
GtoPdb | - | - | 2.7 | pIC50 | - | - | - | Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
GtoPdb | - | - | 2.7 | pIC50 | - | - | - | Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258] | ||||||||
GtoPdb | - | - | 2 | pIC50 | - | - | - | Trends Neurosci (2005) 28: 422-8 [PMID:15979166] |
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050] | ||||||||
GtoPdb | - | - | 4.21 | pKi | - | - | - | J Biol Chem (1994) 269: 20468-74 [PMID:8051145] |
Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390] | ||||||||
GtoPdb | - | - | 2 | pKd | 10000000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
Kv1.6 in Human [GtoPdb: 543] [UniProtKB: P17658] | ||||||||
GtoPdb | - | - | 2.2 | pIC50 | 7000000 | nM | IC50 | EMBO J (1990) 9: 1749-56 [PMID:2347305] |
Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8] | ||||||||
GtoPdb | - | - | 4.1 | pKd | - | - | - | Eur J Hum Genet (2002) 10: 36-43 [PMID:11896454] |
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] | ||||||||
GtoPdb | - | - | 1.1 | pIC50 | - | - | - | J Biol Chem (1998) 273: 5851-7 [PMID:9488722] |
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322] | ||||||||
GtoPdb | - | - | 1.3 | pIC50 | - | - | - | Am J Physiol Renal Physiol (2000) 278: F1013-21 [PMID:10836990] |
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387] | ||||||||
GtoPdb | - | - | 2 | pIC50 | 10000000 | nM | IC50 | Biochem J (2006) 396: 363-9 [PMID:16478442] |
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953] | ||||||||
GtoPdb | - | - | 2.6 | pIC50 | 2600000 | nM | IC50 | Am J Physiol (1998) 274: G901-11 [PMID:9612272] |
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] | ||||||||
GtoPdb | - | - | 3.7 | pIC50 | 200000 | nM | IC50 | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462] | ||||||||
GtoPdb | - | - | 4.2 | pIC50 | 63000 | nM | IC50 | J Physiol (Lond.) (2002) 538: 405-19 [PMID:11790809] |
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956] | ||||||||
GtoPdb | - | - | 3.9 | pIC50 | 140000 | nM | IC50 | Proc Biol Sci (1992) 248: 9-18 [PMID:1381835] |
Kv3.4 in Rat [GtoPdb: 551] [UniProtKB: Q63734] | ||||||||
GtoPdb | - | - | 3.5 | pIC50 | 300000 | nM | IC50 |
FEBS Lett (1991) 278: 211-6 [PMID:1840526]; EMBO J (1992) 11: 2473-86 [PMID:1378392] |
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2] | ||||||||
GtoPdb | - | - | 2 | pIC50 | - | - | - | Mol Cell Biochem (2002) 238: 69-79 [PMID:12349911] |
Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
GtoPdb | - | - | 3.9 | pIC50 | 130000 | nM | IC50 |
Br J Pharmacol (2000) 129: 413-5 [PMID:10711337]; Mol Pharmacol (2000) 58: 591-600 [PMID:10953053] |
Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525] | ||||||||
GtoPdb | - | - | 1.5 | pIC50 | - | - | - | Br J Pharmacol (2000) 129: 413-5 [PMID:10711337] |
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
GtoPdb | - | - | 1.3 | pIC50 | 52000000 | nM | IC50 | J Biol Chem (2008) 283: 30668-76 [PMID:18786918] |
Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
GtoPdb | - | - | 1.5 | pIC50 | - | - | - |
J Biol Chem (2000) 275: 22395-400 [PMID:10787416]; J Biol Chem (2000) 275: 24089-95 [PMID:10816588] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]