tetraethylammonium [Ligand Id: 2343] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL9324
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
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  • Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470]
  • Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388]
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  • KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
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  • KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
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  • KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
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  • KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
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  • Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
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  • Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390]
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  • Kv1.6 in Human [GtoPdb: 543] [UniProtKB: P17658]
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  • Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
  • Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2]
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  • Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322]
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  • Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387]
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  • Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
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  • Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388]
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  • Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462]
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  • Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956]
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  • Kv3.4 in Rat [GtoPdb: 551] [UniProtKB: Q63734]
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  • Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2]
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  • Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526]
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  • Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525]
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  • Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696]
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  • Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes F 6.27 pIC50 540 nM IC50 Biochem. Biophys. Res. Commun. (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes F 4 pKi 100000 nM Ki J. Pharmacol. Exp. Ther. (2000) 292: 1146-1152 [PMID:10688634]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells F 4.33 pKi 46600 nM Ki J. Pharmacol. Exp. Ther. (1998) 287: 800-805 [PMID:9808712]
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes F 5.46 pIC50 3500 nM IC50 Biochem. Biophys. Res. Commun. (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells F 4.28 pKi 52200 nM Ki J. Pharmacol. Exp. Ther. (1998) 287: 800-805 [PMID:9808712]
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470]
ChEMBL Inhibition of Kv1.1 (unknown origin) B 4.52 pIC50 30000 nM IC50 J Med Chem (2017) 60: 2245-2256 [PMID:28225274]
Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388]
GtoPdb - - 3.5 pKd 300000 nM Kd Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb - - 2.7 pIC50 - - - Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb - - 2.7 pIC50 - - - Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb - - 2.7 pIC50 - - - Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
GtoPdb - - 2 pIC50 - - - Trends Neurosci (2005) 28: 422-8 [PMID:15979166]
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
GtoPdb - - 4.21 pKi - - - J Biol Chem (1994) 269: 20468-74 [PMID:8051145]
Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390]
GtoPdb - - 2 pKd 10000000 nM Kd Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.6 in Human [GtoPdb: 543] [UniProtKB: P17658]
GtoPdb - - 2.2 pIC50 7000000 nM IC50 EMBO J (1990) 9: 1749-56 [PMID:2347305]
Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
GtoPdb - - 4.1 pKd - - - Eur J Hum Genet (2002) 10: 36-43 [PMID:11896454]
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2]
GtoPdb - - 1.1 pIC50 - - - J Biol Chem (1998) 273: 5851-7 [PMID:9488722]
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322]
GtoPdb - - 1.3 pIC50 - - - Am J Physiol Renal Physiol (2000) 278: F1013-21 [PMID:10836990]
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387]
GtoPdb - - 2 pIC50 10000000 nM IC50 Biochem J (2006) 396: 363-9 [PMID:16478442]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb - - 2.6 pIC50 2600000 nM IC50 Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388]
GtoPdb - - 3.7 pIC50 200000 nM IC50 Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462]
GtoPdb - - 4.2 pIC50 63000 nM IC50 J Physiol (Lond.) (2002) 538: 405-19 [PMID:11790809]
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956]
GtoPdb - - 3.9 pIC50 140000 nM IC50 Proc Biol Sci (1992) 248: 9-18 [PMID:1381835]
Kv3.4 in Rat [GtoPdb: 551] [UniProtKB: Q63734]
GtoPdb - - 3.5 pIC50 300000 nM IC50 FEBS Lett (1991) 278: 211-6 [PMID:1840526];
EMBO J (1992) 11: 2473-86 [PMID:1378392]
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2]
GtoPdb - - 2 pIC50 - - - Mol Cell Biochem (2002) 238: 69-79 [PMID:12349911]
Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526]
GtoPdb - - 3.9 pIC50 130000 nM IC50 Br J Pharmacol (2000) 129: 413-5 [PMID:10711337];
Mol Pharmacol (2000) 58: 591-600 [PMID:10953053]
Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525]
GtoPdb - - 1.5 pIC50 - - - Br J Pharmacol (2000) 129: 413-5 [PMID:10711337]
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696]
GtoPdb - - 1.3 pIC50 52000000 nM IC50 J Biol Chem (2008) 283: 30668-76 [PMID:18786918]
Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82]
GtoPdb - - 1.5 pIC50 - - - J Biol Chem (2000) 275: 22395-400 [PMID:10787416];
J Biol Chem (2000) 275: 24089-95 [PMID:10816588]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]