H-8 [Ligand Id: 2348] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL148333
  • cAMP-dependent protein kinase alpha-catalytic subunit in Rabbit [ChEMBL: CHEMBL4885] [UniProtKB: Q95J97]
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  • Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
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  • Protein kinase Pfmrk in Plasmodium falciparum [ChEMBL: CHEMBL4090] [UniProtKB: P90584]
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  • CNGA1 in Rat [GtoPdb: 394] [UniProtKB: Q62927]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cAMP-dependent protein kinase alpha-catalytic subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4885] [UniProtKB: Q95J97]
ChEMBL Inhibitory constant against cAPK (PKA) B 5.92 pKi 1200 nM Ki J. Biol. Chem. (1996) 271: 26157-26164 [PMID:8824261]
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL Inhibitory constant against MLCK B 4.17 pKi 68000 nM Ki J. Biol. Chem. (1996) 271: 26157-26164 [PMID:8824261]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum D6 F 4.13 pIC50 >74000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4961-4966 [PMID:17588749]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum W2 F 4.43 pIC50 >37000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4961-4966 [PMID:17588749]
Protein kinase Pfmrk in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4090] [UniProtKB: P90584]
ChEMBL Inhibition of Plasmodium falciparum Pfmrk B 4.15 pIC50 70000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4961-4966 [PMID:17588749]
CNGA1 in Rat [GtoPdb: 394] [UniProtKB: Q62927]
GtoPdb - - 3.5 pIC50 - - - Neurosci. Lett. (1997) 233: 37-40 [PMID:9324234]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]