H-8 [Ligand Id: 2348] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL148333
  • cAMP-dependent protein kinase alpha-catalytic subunit in Rabbit [ChEMBL: CHEMBL4885] [UniProtKB: Q95J97]
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  • Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
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  • Protein kinase Pfmrk in Plasmodium falciparum [ChEMBL: CHEMBL4090] [UniProtKB: P90584]
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  • CNGA1 in Rat [GtoPdb: 394] [UniProtKB: Q62927]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cAMP-dependent protein kinase alpha-catalytic subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4885] [UniProtKB: Q95J97]
ChEMBL Inhibitory constant against cAPK (PKA) B 5.92 pKi 1200 nM Ki J Biol Chem (1996) 271: 26157-26164 [PMID:8824261]
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL Inhibitory constant against MLCK B 4.17 pKi 68000 nM Ki J Biol Chem (1996) 271: 26157-26164 [PMID:8824261]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum D6 F 4.13 pIC50 >74000 nM IC50 Bioorg Med Chem Lett (2007) 17: 4961-4966 [PMID:17588749]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum W2 F 4.43 pIC50 >37000 nM IC50 Bioorg Med Chem Lett (2007) 17: 4961-4966 [PMID:17588749]
Protein kinase Pfmrk in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4090] [UniProtKB: P90584]
ChEMBL Inhibition of Plasmodium falciparum Pfmrk B 4.15 pIC50 70000 nM IC50 Bioorg Med Chem Lett (2007) 17: 4961-4966 [PMID:17588749]
CNGA1 in Rat [GtoPdb: 394] [UniProtKB: Q62927]
GtoPdb - - 3.5 pIC50 - - - Neurosci Lett (1997) 233: 37-40 [PMID:9324234]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]