Cs+ [Ligand Id: 2356] activity data from GtoPdb

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  • HCN1 in Human [GtoPdb: 400] [UniProtKB: O60741]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 HCN1 Human
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  • HCN2 in Human [GtoPdb: 401] [UniProtKB: Q9UL51]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 HCN2 Human
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  • HCN3 in Human [GtoPdb: 402] [UniProtKB: Q9P1Z3]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 HCN3 Human
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  • HCN4 in Human [GtoPdb: 403] [UniProtKB: Q9Y3Q4]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 HCN4 Human
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  • Kir1.1 in Rat [GtoPdb: 429] [UniProtKB: P35560]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 Kir1.1 Rat
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  • Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 Kir2.1 Mouse
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  • Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
  • Kir2.3 in Mouse [GtoPdb: 432] [UniProtKB: P52189]
  • This target only has 1 pki data point
  • 0
7 _lig_chart_7 Kir2.3 HumanMouse
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  • Kir2.4 in Human [GtoPdb: 433] [UniProtKB: Q9UNX9]
  • Kir2.4 in Rat [GtoPdb: 433] [UniProtKB: O70596]
  • This target only has 1 pki data point
  • 2.09
8 _lig_chart_8 Kir2.4 HumanRat
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  • Kir3.4 in Rat [GtoPdb: 437] [UniProtKB: P48548]
  • This target only has 0 pki data point
  • 0
9 _lig_chart_9 Kir3.4 Rat
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  • Kir7.1 in Human [GtoPdb: 443] [UniProtKB: O60928]
  • This target only has 1 pki data point
  • 1.6
10 _lig_chart_10 Kir7.1 Human
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  • Kv12.2 in Human [GtoPdb: 576] [UniProtKB: Q9ULD8]
  • This target only has 0 pki data point
  • 0
11 _lig_chart_11 Kv12.2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCN1 in Human [GtoPdb: 400] [UniProtKB: O60741]
GtoPdb - - 3.7 pIC50 201 nM IC50 J Biol Chem (2005) 280: 34635-43 [PMID:16043489]
HCN2 in Human [GtoPdb: 401] [UniProtKB: Q9UL51]
GtoPdb - - 3.7 pIC50 206 nM IC50 J Biol Chem (2005) 280: 34635-43 [PMID:16043489]
HCN3 in Human [GtoPdb: 402] [UniProtKB: Q9P1Z3]
GtoPdb - - 3.8 pIC50 157000 nM IC50 J Biol Chem (2005) 280: 34635-43 [PMID:16043489]
HCN4 in Human [GtoPdb: 403] [UniProtKB: Q9Y3Q4]
GtoPdb - - 3.8 pIC50 175 nM IC50 J Biol Chem (2005) 280: 34635-43 [PMID:16043489]
Kir1.1 in Rat [GtoPdb: 429] [UniProtKB: P35560]
GtoPdb - - 2.9 pIC50 - - - Am J Physiol (1996) 271: C1949-56 [PMID:8997197]
Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561]
GtoPdb - - 4 pKd - - - J Physiol (Lond.) (1996) 493 ( Pt 3): 643-9 [PMID:8799888]
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
GtoPdb - - 4.52 pKi - - - J Biol Chem (1994) 269: 20468-74 [PMID:8051145]
Kir2.3 in Mouse [GtoPdb: 432] [UniProtKB: P52189]
GtoPdb - - 4.96 pIC50 - - - FEBS Lett (1994) 346: 251-6 [PMID:8013643];
FEBS Lett (1994) 353: 37-42 [PMID:7926018]
Kir2.4 in Human [GtoPdb: 433] [UniProtKB: Q9UNX9]
GtoPdb - - 4.08 pKd - - - Am J Physiol, Cell Physiol (2000) 279: C771-84 [PMID:10942728]
Kir2.4 in Rat [GtoPdb: 433] [UniProtKB: O70596]
GtoPdb - - 2.09 pKi - - - J Neurosci (1998) 18: 4096-105 [PMID:9592090]
Kir3.4 in Rat [GtoPdb: 437] [UniProtKB: P48548]
GtoPdb - - 4 pEC50 - - - Nature (1995) 374: 135-41 [PMID:7877685]
Kir7.1 in Human [GtoPdb: 443] [UniProtKB: O60928]
GtoPdb - - 1.6 pKi - - - Neuron (1998) 20: 995-1005 [PMID:9620703];
J Neurosci (1998) 18: 8625-36 [PMID:9786970];
FEBS Lett (1998) 434: 171-6 [PMID:9738472]
Kv12.2 in Human [GtoPdb: 576] [UniProtKB: Q9ULD8]
GtoPdb - - 1.2 pKd - - - Eur J Neurosci (2002) 16: 415-28 [PMID:12193184]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.