ChEMBL ligand: CHEMBL107 (Colchcine, (-)-colchicine, Colchicine, Colchicinum, Colchineos, Colchisol, Colcrys, Gloperba, Lodoco, Mitigare, NSC-757)
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 3/Solute carrier family 22 member 3 in Human [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751] There should be some charts here, you may need to enable JavaScript!
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] Tubulin in Bovine [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3] There should be some charts here, you may need to enable JavaScript!
Tubulin alpha chain in Pig [ChEMBL: CHEMBL3658] [UniProtKB: P02550] There should be some charts here, you may need to enable JavaScript!
tubulin beta class I/Tubulin beta-5 chain in Human [ChEMBL: CHEMBL5444] [GtoPdb: 2640] [UniProtKB: P07437] There should be some charts here, you may need to enable JavaScript!
Tubulin beta chain in Bovine [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856] There should be some charts here, you may need to enable JavaScript!
Tubulin polymerization-promoting protein in Bovine [ChEMBL: CHEMBL2366491] [UniProtKB: Q27957] There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] There should be some charts here, you may need to enable JavaScript!
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416] There should be some charts here, you may need to enable JavaScript!
TAS2R4 in Human [GtoPdb: 661] [UniProtKB: Q9NYW5] There should be some charts here, you may need to enable JavaScript!
TAS2R46 in Human [GtoPdb: 679] [UniProtKB: P59540] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 4 in Human [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of human PIM1 measured after 5 mins by ELISA relative to control	B	5.37	pIC50	4300	nM	IC50	Eur J Med Chem (2017) 134: 357-365 [PMID:28431341]
Organic cation transporter 3/Solute carrier family 22 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HEK293 cells	F	6.92	pKi	120	nM	Ki	Nat Neurosci (1998) 1: 349-351 [PMID:10196521]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7]
ChEMBL	Binding affinity to tubulin (unknown origin) assessed as affinity constant by SPR analysis	B	4.47	pKd	33700	nM	Kd	J Med Chem (2023) 66: 6697-6714 [PMID:37145846]
ChEMBL	Binding affinity to tubulin (unknown origin) assessed as dissociation constant by SPR analysis	B	4.63	pKd	23400	nM	Kd	Eur J Med Chem (2023) 248: 115085-115085 [PMID:36621138]
ChEMBL	Binding affinity to tubulin (unknown origin) assessed as dissociation constant by SPR analysis	B	4.95	pKd	11300	nM	Kd	Eur J Med Chem (2019) 170: 73-86 [PMID:30878833]
ChEMBL	Displacement of fluorescent probe (R)-(+)-ethyl 5-amino2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate from tubulin colchicine binding site (unknown origin) assessed as dissociation constant	B	5.82	pKd	1500	nM	Kd	J Med Chem (2024) 67: 2619-2630 [PMID:38294341]
ChEMBL	Binding affinity to tubulin (unknown origin) by ITC method	B	7.24	pKd	58	nM	Kd	Eur J Med Chem (2017) 141: 460-472 [PMID:29055869]
ChEMBL	Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) after 2 hrs by scintillation proximity assay	B	5.62	pKi	2400	nM	Ki	J Med Chem (2013) 56: 8008-8018 [PMID:24106982]
ChEMBL	Inhibition of brain tubulin (unknown origin) polymerization measured up to 15 to 30 mins	B	5.11	pIC50	7800	nM	IC50	J Med Chem (2015) 58: 6678-6696 [PMID:26226379]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.15	pIC50	7000	nM	IC50	J Med Chem (2023) 66: 627-640 [PMID:36516438]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization by spectrophotometry	B	5.27	pIC50	5400	nM	IC50	Bioorg Med Chem (2014) 22: 4917-4923 [PMID:25059503]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) by fluorescence based analysis	B	5.37	pIC50	4280	nM	IC50	Eur J Med Chem (2022) 238: 114450-114450 [PMID:35576703]
ChEMBL	In vitro inhibition of tubulin polymerization.	F	5.38	pIC50	4200	nM	IC50	J Med Chem (1993) 36: 1474-1479 [PMID:8496915]
ChEMBL	Inhibition of tubulin polymerization	F	5.48	pIC50	3300	nM	IC50	J Med Chem (2006) 49: 6656-6659 [PMID:17154496]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins by spectrophotometry	B	5.49	pIC50	3200	nM	IC50	J Med Chem (2013) 56: 123-149 [PMID:23214452]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition by turbidity based spectrophotometer analysis	B	5.49	pIC50	3200	nM	IC50	ACS Med Chem Lett (2017) 8: 521-526 [PMID:28523104]
ChEMBL	Inhibition of tubulin polymerization	F	5.49	pIC50	3200	nM	IC50	J Med Chem (2006) 49: 6412-6415 [PMID:17034147]
ChEMBL	Inhibition of tubulin (unknown origin) assembly preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric analysis	B	5.49	pIC50	3200	nM	IC50	J Med Chem (2015) 58: 5789-5807 [PMID:26132075]
ChEMBL	Inhibition of tubulin polymerization	B	5.49	pIC50	3200	nM	IC50	J Med Chem (2004) 47: 6120-6123 [PMID:15566282]
ChEMBL	Inhibition of tubulin polymerization	B	5.49	pIC50	3200	nM	IC50	J Med Chem (2007) 50: 2865-2874 [PMID:17497841]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization incubated 15 mins prior to GTP addition by spectrophotometry	B	5.49	pIC50	3200	nM	IC50	J Med Chem (2014) 57: 6531-6552 [PMID:25025991]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins followed by GTP addition and measured for 20 mins by spectrophotometry	B	5.49	pIC50	3200	nM	IC50	Eur J Med Chem (2020) 185: 111828-111828 [PMID:31727471]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric method	B	5.49	pIC50	3200	nM	IC50	Eur J Med Chem (2018) 152: 283-297 [PMID:29730191]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) assessed as reduction in fluorescence intensity measured every 60 secs for 1 hr by microplate reader analysis	B	5.52	pIC50	2990	nM	IC50	Eur J Med Chem (2023) 252: 115281-115281 [PMID:36940611]
ChEMBL	Inhibition of tubulin (unknown origin) by competitive binding assay	B	5.53	pIC50	2930	nM	IC50	Eur J Med Chem (2022) 227: 113897-113897 [PMID:34649064]
ChEMBL	Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins	B	5.54	pIC50	2900	nM	IC50	J Med Chem (2007) 50: 4548-4552 [PMID:17685504]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) measured every 30 secs for 90 mins	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem Lett (2021) 40: 127968-127968 [PMID:33753264]
ChEMBL	Inhibition of tubulin polymerization	B	5.57	pIC50	2700	nM	IC50	J Med Chem (2006) 49: 2357-2360 [PMID:16570932]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) assessed as fluorescence intensity emission at 410 nm for 60 mins	B	5.58	pIC50	2650	nM	IC50	J Med Chem (2022) 65: 4687-4708 [PMID:35282680]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) by DAPI staining-based fluorescence microscopy	B	5.59	pIC50	2600	nM	IC50	J Med Chem (2014) 57: 6364-6382 [PMID:25061803]
ChEMBL	Displacement of [3H]-colchicine from tubulin (unknown origin) preincubated with protein for 1 hr followed by [3H]-colchicine addition measured after 3 hrs by scintillation counting analysis	B	5.66	pIC50	2210	nM	IC50	J Med Chem (2015) 58: 6549-6558 [PMID:26241032]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) by turbidimetric analysis	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2021) 64: 15702-15715 [PMID:34670362]
ChEMBL	Inhibition of tubulin polymerization	F	5.72	pIC50	1900	nM	IC50	J Med Chem (1993) 36: 1146-1156 [PMID:8387598]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins in presence of GTP by fluorescence-based tubulin polymerization assay kit	B	5.75	pIC50	1770	nM	IC50	Eur J Med Chem (2021) 209: 112904-112904 [PMID:33077264]
ChEMBL	Inhibition of microtubule polymerization	F	5.77	pIC50	1700	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2761-2764 [PMID:16504507]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2020) 63: 10618-10651 [PMID:32432867]
ChEMBL	In vitro inhibition of mammalian tubulin polymerization by 50%	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1998) 41: 1956-1961 [PMID:9599244]
ChEMBL	Inhibition of Tubulin polymerization after 20 minutes of administration at 30 degree Centigrade	F	5.82	pIC50	1500	nM	IC50	J Med Chem (1997) 40: 961-966 [PMID:9083485]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) incubated for 20 mins	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2020) 63: 10618-10651 [PMID:32432867]
ChEMBL	Inhibition of [3H]colchicine binding to tubulin (unknown origin) by competitive binding assay	B	5.83	pIC50	1470	nM	IC50	J Med Chem (2022) 65: 4687-4708 [PMID:35282680]
ChEMBL	Displacement of [3H]colchicine from tubulin (unknown origin) incubated for 60 mins by competitive binding assay	B	5.84	pIC50	1460	nM	IC50	Eur J Med Chem (2020) 203: 112506-112506 [PMID:32688198]
ChEMBL	Inhibition of tubulin polymerization in human MCF7 cells by ELISA	B	5.85	pIC50	1400	nM	IC50	RSC Med Chem (2022) 13: 929-943 [PMID:36092142]
ChEMBL	Inhibition of tubulin polymerization in human K562 cells	B	5.85	pIC50	1400	nM	IC50	Eur J Med Chem (2010) 45: 3354-3364 [PMID:20546980]
ChEMBL	In vitro inhibitory activity against tubulin polymerization (10 uM)	B	5.85	pIC50	1400	nM	IC50	J Med Chem (1998) 41: 2333-2338 [PMID:9632366]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) preincubated for 10 mins followed by GTP addition measured after 20 mins by Coomassie blue staining based SDS-PAGE analysis	B	5.88	pIC50	1320	nM	IC50	Eur J Med Chem (2017) 141: 460-472 [PMID:29055869]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) relative to control	B	5.89	pIC50	1280	nM	IC50	Bioorg Med Chem (2020) 28: 115674-115674 [PMID:33065442]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) measured every minute	B	5.94	pIC50	1150	nM	IC50	Eur J Med Chem (2023) 255: 115366-115366 [PMID:37099835]
ChEMBL	Displacement of [3H]colchicine from biotinylated tubulin by scintillation proximity assay	B	5.98	pIC50	1050	nM	IC50	J Med Chem (2007) 50: 6059-6066 [PMID:17973361]
ChEMBL	Inhibition of [3H]colchicine binding to beta tubulin	B	6.3	pIC50	500	nM	IC50	J Med Chem (2006) 49: 5769-5776 [PMID:16970401]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 45 mins followed by GTP addition measured after 2 hrs by fluorescence assay	B	6.44	pIC50	360	nM	IC50	Eur J Med Chem (2015) 93: 93-100 [PMID:25659770]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) incubated for 1 hr by fluorescence based assay	B	6.72	pIC50	190	nM	IC50	RSC Med Chem (2020) 11: 327-348 [PMID:33479639]
GtoPdb	-	-	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2761-4 [PMID:16504507]
ChEMBL	Inhibition of tubulin polymerization in human HeLa cells assessed as dynamic tyrosinated microtubules content by incubated for 2 hrs by immunofluorescence staining based assay	B	6.7	pEC50	200	nM	EC50	Eur J Med Chem (2021) 215: 113275-113275 [PMID:33618157]
Tubulin in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3]
ChEMBL	Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetrically	B	5.58	pIC50	2620	nM	IC50	Eur J Med Chem (2015) 99: 125-137 [PMID:26070164]
ChEMBL	Inhibition of bovine brain tubulin polymerization after 30 mins	B	5.72	pIC50	1900	nM	IC50	Bioorg Med Chem (2015) 23: 4230-4236 [PMID:26160020]
Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550]
ChEMBL	Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assay	B	5.6	pKi	2500	nM	Ki	Bioorg Med Chem Lett (1991) 1: 471-476
ChEMBL	Inhibition of tubulin polymerization interacting at the colchicine binding site.	B	5.38	pIC50	4168.69	nM	IC50	J Med Chem (2000) 43: 167-176 [PMID:10649972]
ChEMBL	Tested for 50 % inhibition of tubulin polymerization by turbidimetric assay	B	5.72	pIC50	1900	nM	IC50	Bioorg Med Chem Lett (1993) 3: 581-584
ChEMBL	The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.	F	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (1992) 2: 1257-1262
ChEMBL	Inhibition of tubulin polymerization (ITP)	B	6.1	pIC50	800	nM	IC50	J Med Chem (2001) 44: 3932-3936 [PMID:11689079]
tubulin beta class I/Tubulin beta-5 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5444] [GtoPdb: 2640] [UniProtKB: P07437]
ChEMBL	Inhibition of tubulin beta polymerization in human Caco2 cells after 48 hrs by ELISA	B	5.11	pIC50	7710	nM	IC50	Medchemcomm (2018) 9: 1511-1528 [PMID:30288225]
ChEMBL	Inhibition of tubulin beta polymerization in human MCF7 cells after 18 to 24 hrs by ELISA based spectrophotometric analysis	B	5.16	pIC50	6930	nM	IC50	Bioorg Med Chem (2018) 26: 3474-3490 [PMID:29793751]
ChEMBL	Inhibition of tubulin beta polymerization in human MCF7 cells after 48 hrs by ELISA	B	5.34	pIC50	4590	nM	IC50	Medchemcomm (2018) 9: 1511-1528 [PMID:30288225]
GtoPdb	-	-	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2761-4 [PMID:16504507]
Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856]
ChEMBL	Binding constant at colchicine site of bovine brain tubulin	B	6.11	pKi	780	nM	Ki	Bioorg Med Chem Lett (2002) 12: 465-469 [PMID:11814821]
ChEMBL	Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tubulin concentration	B	5.46	pIC50	3500	nM	IC50	Bioorg Med Chem Lett (1993) 3: 565-570
ChEMBL	Inhibitory effect on the polymerization of purified bovine brain tubulin.	F	5.62	pIC50	2400	nM	IC50	J Med Chem (1990) 33: 567-571 [PMID:2299625]
ChEMBL	Inhibition of tubulin polymerization	F	6.1	pIC50	800	nM	IC50	J Med Chem (1994) 37: 1126-1135 [PMID:8164254]
ChEMBL	Inhibition of bovine tubulin polymerization	F	6.1	pIC50	800	nM	IC50	J Med Chem (1997) 40: 2266-2275 [PMID:9216846]
Tubulin polymerization-promoting protein in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366491] [UniProtKB: Q27957]
ChEMBL	Inhibition of Bos taurus (bovine) brain tubulin polymerization	B	6.12	pEC50	750	nM	EC50	Bioorg Med Chem Lett (2001) 11: 1393-1396 [PMID:11378362]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb	-	-	3.5	pIC50	324000	nM	IC50
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
GtoPdb	-	-	4.2	pIC50	64000	nM	IC50
TAS2R4 in Human [GtoPdb: 661] [UniProtKB: Q9NYW5]
GtoPdb	-	-	2.99	pEC50	1025000	nM	EC50	Chem Senses (2010) 35: 157-70 [PMID:20022913]
TAS2R46 in Human [GtoPdb: 679] [UniProtKB: P59540]
GtoPdb	-	-	2.8	pEC50	1580000	nM	EC50	Chem Senses (2010) 35: 157-70 [PMID:20022913]
bromodomain containing 4 in Human [GtoPdb: 1945] [UniProtKB: O60885]
GtoPdb	-	-	4.7	pKd	20000	nM	Kd	Angew Chem Int Ed Engl (2013) 52: 14055-9 [PMID:24272870]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]