ChEMBL ligand: CHEMBL284348 (Ampyra, Ampyra Extended Release, Dalfampridine, EL-970, Fampridine, Fampridine (4-aminopyridine), Fampridine accord, Fampyra, NSC-15041)
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] There should be some charts here, you may need to enable JavaScript!
Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] There should be some charts here, you may need to enable JavaScript!
Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385] There should be some charts here, you may need to enable JavaScript!
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] There should be some charts here, you may need to enable JavaScript!
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] There should be some charts here, you may need to enable JavaScript!
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322] There should be some charts here, you may need to enable JavaScript!
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387] There should be some charts here, you may need to enable JavaScript!
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953] There should be some charts here, you may need to enable JavaScript!
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] There should be some charts here, you may need to enable JavaScript!
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462] There should be some charts here, you may need to enable JavaScript!
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956] There should be some charts here, you may need to enable JavaScript!
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2] Kv4.1 in Mouse [GtoPdb: 552] [UniProtKB: Q03719] There should be some charts here, you may need to enable JavaScript!
Kv4.2 in Mouse [GtoPdb: 553] [UniProtKB: Q9Z0V2] There should be some charts here, you may need to enable JavaScript!
Kv4.3 in Mouse [GtoPdb: 554] [UniProtKB: Q9Z0V1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470]
ChEMBL	Inhibition of Kv1.1 (unknown origin)	B	4.05	pIC50	89000	nM	IC50	J Med Chem (2017) 60: 2245-2256 [PMID:28225274]
Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142]
GtoPdb	-	-	3.2	pKd	590000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385]
GtoPdb	-	-	1.9	pIC50	12500000	nM	IC50	EMBO J (1989) 8: 3235-44 [PMID:2555158]
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460]
GtoPdb	-	-	3.6	pKd	270000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2]
GtoPdb	-	-	3.8	pKd	-	-	-	J Gen Physiol (2006) 128: 133-45 [PMID:16801386]
GtoPdb	-	-	3.6	pIC50	245000	nM	IC50	J Biol Chem (1998) 273: 5851-7 [PMID:9488722]
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322]
GtoPdb	-	-	2.8	pIC50	1580000	nM	IC50	Am J Physiol Renal Physiol (2000) 278: F1013-21 [PMID:10836990]
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387]
GtoPdb	-	-	3.3	pIC50	500000	nM	IC50	J Gen Physiol (1993) 102: 797-816 [PMID:8301258]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb	-	-	2.8	pIC50	1500000	nM	IC50	Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388]
GtoPdb	-	-	4.5	pIC50	29000	nM	IC50	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462]
GtoPdb	-	-	4.6	pIC50	24000	nM	IC50	J Physiol (Lond.) (2002) 538: 405-19 [PMID:11790809]
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956]
GtoPdb	-	-	2.9	pIC50	-	-	-	Proc Biol Sci (1992) 248: 9-18 [PMID:1381835]
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2]
GtoPdb	-	-	2	pIC50	-	-	-	Genomics (2000) 64: 144-54 [PMID:10729221]
Kv4.1 in Mouse [GtoPdb: 552] [UniProtKB: Q03719]
GtoPdb	-	-	2	pIC50	-	-	-	Proc Natl Acad Sci USA (2002) 99: 1035-40 [PMID:11805342]
Kv4.2 in Mouse [GtoPdb: 553] [UniProtKB: Q9Z0V2]
GtoPdb	-	-	2.3	pIC50	-	-	-	Mol Pharmacol (2006) 69: 718-26 [PMID:16317109]
Kv4.3 in Mouse [GtoPdb: 554] [UniProtKB: Q9Z0V1]
GtoPdb	-	-	2.4	pIC50	-	-	-	Br J Pharmacol (2006) 149: 676-86 [PMID:17016508]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]