cinnamaldehyde [Ligand Id: 2423] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL293492 (Abion ca, .beta.-phenylacrolein, Cinnamal, Cinnamaldehyde, Cinnamic aldehyde, FEMA NO. 2286, NSC-16935, NSC-40346, XC-800, Zimtaldehyde)
  • 5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
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  • Cell division protein ftsZ in Escherichia coli K-12 [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
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  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method B 4.46 pIC50 35000 nM IC50 Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653]
Cell division protein ftsZ in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL Inhibition of Escherichia coli FtsZ polymerization B 5.16 pIC50 6860 nM IC50 Eur. J. Med. Chem. (2015) 95: 1-15 [PMID:25791674]
ChEMBL Inhibition of Escherichia coli FtsZ GTPase activity B 5.24 pIC50 5810 nM IC50 Eur. J. Med. Chem. (2015) 95: 1-15 [PMID:25791674]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count F 4.29 pEC50 51400 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 276-279 [PMID:19945872]
ChEMBL Activation of TRPA1 B 4.72 pEC50 19000 nM EC50 Nature (2007) 445: 541-545 [PMID:17237762]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 5.05 pEC50 9000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 5.07 pEC50 8511.38 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels B 5.19 pEC50 6500 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb - - 4.2 pEC50 63000 nM EC50 Neuron (2004) 41: 849-57 [PMID:15046718]
ChEMBL Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis B 4.21 pEC50 61000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]