eugenol [Ligand Id: 2425] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL42710 (4-allylcatechol 2-methyl ether, Bioxeda, Caryophillic acid, Dentogum, Eugenol, FEMA NO. 2467, NSC-209525, NSC-8895)
  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
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  • 5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
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  • TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay F 4.72 pIC50 19054.61 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2111-2114 [PMID:20226658]
ChEMBL Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay F 4.72 pIC50 19000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2111-2114 [PMID:20226658]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method B 4.59 pIC50 26000 nM IC50 Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 B 4.96 pIC50 11000 nM IC50 J. Nat. Prod. (2005) 68: 985-991 [PMID:16038536]
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb Patch clamp electrophysiology - 2.5 pEC50 - - - Nat Neurosci (2006) 9: 628-35 [PMID:16617338]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]