(-)-menthol [Ligand Id: 2430] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL470670 (L-menthol, Levomenthol)
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
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  • TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7]
  • TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
  • TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455]
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  • Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
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  • TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay B 4.02 pEC50 96000 nM EC50 ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
GtoPdb Calcium imaging, patch clamp - 4.5 pEC50 28400 nM EC50 J Neurosci (2008) 28: 9640-51 [PMID:18815250];
J Neurosci (2007) 27: 9874-84 [PMID:17855602]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb - - 4.2 pIC50 - - - Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7]
GtoPdb - - 4.6 pEC50 25100 nM EC50 Nature (2004) 430: 748-54 [PMID:15306801]
ChEMBL Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay B 5 pEC50 10100 nM EC50 ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
GtoPdb - - 5.4 pEC50 - - - J Neurosci (2004) 24: 5364-9 [PMID:15190109];
Br J Pharmacol (2004) 141: 737-45 [PMID:14757700]
TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455]
GtoPdb - - 4.2 pEC50 - - - Nature (2002) 416: 52-8 [PMID:11882888]
Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rabbit ventricular myocytes F 4.13 pIC50 74600 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb Patch clamp electrophysiology and calcium imaging - 1.7 pEC50 19952624 nM EC50 Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]