(-)-menthol [Ligand Id: 2430] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL470670 (Levomenthol, L-menthol)
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
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  • TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7]
  • TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
  • TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455]
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  • Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
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  • TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay B 4.02 pEC50 96000 nM EC50 ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
GtoPdb Calcium imaging, patch clamp - 4.5 pEC50 28400 nM EC50 J Neurosci (2008) 28: 9640-51 [PMID:18815250];
J Neurosci (2007) 27: 9874-84 [PMID:17855602]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb - - 4.2 pIC50 - - - Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7]
ChEMBL Agonist activity at TRPM8 (unknown origin) by fluorometric imaging plate reader analysis B 4.22 pEC50 60000 nM EC50 J Med Chem (2016) 59: 10006-10029 [PMID:27437828]
GtoPdb - - 4.6 pEC50 25100 nM EC50 Nature (2004) 430: 748-54 [PMID:15306801]
ChEMBL Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay B 5 pEC50 10100 nM EC50 ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
GtoPdb - - 5.4 pEC50 - - - J Neurosci (2004) 24: 5364-9 [PMID:15190109];
Br J Pharmacol (2004) 141: 737-45 [PMID:14757700]
TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455]
GtoPdb - - 4.2 pEC50 - - - Nature (2002) 416: 52-8 [PMID:11882888]
Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rabbit ventricular myocytes F 4.13 pIC50 74600 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb Patch clamp electrophysiology and calcium imaging - 1.7 pEC50 19952624 nM EC50 Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]