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ChEMBL ligand: CHEMBL470670 (Levomenthol, L-menthol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
ChEMBL | Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay | B | 4.02 | pEC50 | 96000 | nM | EC50 | ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604] |
GtoPdb | Calcium imaging, patch clamp | - | 4.5 | pEC50 | 28400 | nM | EC50 |
J Neurosci (2008) 28: 9640-51 [PMID:18815250]; J Neurosci (2007) 27: 9874-84 [PMID:17855602] |
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
GtoPdb | - | - | 4.2 | pIC50 | - | - | - | Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128] |
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7] | ||||||||
ChEMBL | Agonist activity at TRPM8 (unknown origin) by fluorometric imaging plate reader analysis | B | 4.22 | pEC50 | 60000 | nM | EC50 | J Med Chem (2016) 59: 10006-10029 [PMID:27437828] |
GtoPdb | - | - | 4.6 | pEC50 | 25100 | nM | EC50 | Nature (2004) 430: 748-54 [PMID:15306801] |
ChEMBL | Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay | B | 5 | pEC50 | 10100 | nM | EC50 | ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604] |
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5] | ||||||||
GtoPdb | - | - | 5.4 | pEC50 | - | - | - |
J Neurosci (2004) 24: 5364-9 [PMID:15190109]; Br J Pharmacol (2004) 141: 737-45 [PMID:14757700] |
TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455] | ||||||||
GtoPdb | - | - | 4.2 | pEC50 | - | - | - | Nature (2002) 416: 52-8 [PMID:11882888] |
Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rabbit ventricular myocytes | F | 4.13 | pIC50 | 74600 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] | ||||||||
GtoPdb | Patch clamp electrophysiology and calcium imaging | - | 1.7 | pEC50 | 19952624 | nM | EC50 | Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]