dihydrosphingosine [Ligand Id: 2453] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL448741 (DL-erythro-Dihydrosphingosine, Dihydrospingosine)
  • Cholesteryl ester transfer protein in Human [ChEMBL: CHEMBL3572] [UniProtKB: P11597]
  • This target only has 0 pki data point
  • 0
1 CHEMBL448741_lig_chart_1 Cholesteryl ester transfer protein Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
2 CHEMBL448741_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
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  • TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
  • This target only has 0 pki data point
  • 0
3 CHEMBL448741_lig_chart_3 TRPM3 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cholesteryl ester transfer protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3572] [UniProtKB: P11597]
ChEMBL Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP) B 4.89 pIC50 12900 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 1481-1482
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
GtoPdb - - 4.7 pEC50 - - - Mol Pharmacol (2005) 67: 798-805 [PMID:15550678]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]